血清同型半胱氨酸和尿酸水平对急性冠脉综合征患者近期预后的影响

Effects of Serum Homocysteine and Uric Acid on Short-term Prognosis of Patients With Acute Coronary Syndrome

目的:探讨急性冠脉综合征(ACS)患者血清尿酸(UA)、同型半胱氨酸(Hcy)含量对预后的预测价值。方法:将180例ACS患者,根据空腹血Hcy水平分为A组(5～10μmol/L)、B组(10～15μmol/L)、C组(>15μmol/L),测定各组UA水平。结果:A、B、C组的UA水平分别为(350.00±30.53)μmol/L、(509.00±20.53)μmol/L、(650.00±30.12)μmol/L,3组间两两比较,差异均有统计学意义(P<0.01)。各组间急性心肌梗死、严重心律失常、左室功能不全、心源性猝死等不良事件发生率比较,差异均有统计学意义(P均<0.05).结论:ACS患者随着Hcy水平的升高,UA水平逐渐升高,近期不良事件的发生率增加。UA和Hcy水平可作为预测ACS患者不良预后的指标。

Objective： To explore the predictive value of serum uric acid （UA） and homocysteine （Hcy） on prognosis of patients with acute coronary syndrome （ACS）. Methods： One hundred and eighty patients with ACS were divided into group A （5-10umol/L）, group B （10--15umol/L） and group C （〉15umol / L） according to the level of fasting plasma Hcy, and level of UA was detected in all groups. Results： Levels of UA were （350. 00 ± 30. 53）umol/L, （509. 00 ± 20. 53） umol/L, （650. 00 ± 30. 12） umol/L respectively, the differences between pair wise were statistically significant （P〈0.01）. There were statistical differences in incidences of adverse events such as acute myocardial infarction, severe arrhythmia and left ventricular dysfunction among 3 groups （P〈0.05）. Conclusions： With the increased level of Hcy, the level of UA gradually increases, and the incidences of recent adverse events increase. Levels of UA and Hcy can be used as indicators of poor prognosis in patients with ACS.