酪氨酸酶抑制剂的研究进展

Research progress in tyrosinase inhibitor

酪氨酸酶(tyrosinase,EC1·14·18·1)广泛存在于自然界中,其化学本质是含铜蛋白,是黑色素生物合成的关键酶和限速酶。酪氨酸酶的活性与色素沉着性疾病、食品褐变等均有密切关系。抑制酪氨酸酶活性对人类皮肤色素疾病的治疗、食品保鲜及农业抗虫领域具有重要意义。本文对近年来酪氨酸酶抑制剂的来源、制备方法、抑制机理进行了综述。

Tyrosinase（EC1.14.18.1）is the key enzyme and rate-limiting enzyme in melanin biosynthesis which is widespread in nature. The chemical nature of tyrosinase is copper-containing protein. The activity of tyrosinase is closely related to dermatological disorders,the browning of food and so on. Inhibiting the activity of tyrosinase is significant for the curing of dermatosis,keeping food fresh and making pesticides in agriculture. In recent years,the scientist had conducted the thorough research of the tyrosinase inhibitors. The origin,method and inhibitory mechanism of tyrosinase inhibitor were summarized in this article.