代谢综合征子代青春期糖脂代谢和抗氧化防御水平检测结果分析

Analysis on Glucose and Lipid Metabolism and Antioxidant Defense Level in Adolescent with Paternal Metabolic Syndrome

目的探讨代谢综合征(MS)子代在青春晚期糖脂代谢、抗氧化酶活性、总抗氧化能力与健康人子代的差异,为进一步探讨代谢综合征的发病机理提供参考。方法采用病例对照研究,对30例代谢综合征患者子代和74例健康人子代进行体格检查,包括身高、体质量、腰围(WC)和血压(BP)、计算体质量指数(BMI)、腰围/身高(WHtR)、腰围/臀围(WHR),并检测血清空腹血糖(FPG)、血脂水平、总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-PX)活性。结果 MS患者青春期子代的肥胖指标和血压水平(腰围、腰围身高比、腰臀比、舒张压值)及血脂异常率(低、高密度脂蛋白胆固醇率)均高于健康成人群的青春期子代(P值均<0.05),而SOD和GSH-PX活性显著低于对照组(P值均<0.01)。SOD和GSH-PX的活性与WC,WHtR,WHR,DBP呈显著负相关(P值均<0.05),与HDL-C呈显著正相关(P<0.05),SOD活性与DBP也呈显著负相关(P<0.05)。结论代谢综合征患者子代MS和MS相关组分异常检出率均高于正常人群子代,且抗氧化酶活性低于正常人群子代。抗氧化酶的活性与MS组分(肥胖、血脂异常)有显著相关性。

Objective To study the differences of glucose and lipid metabolism,activities of antioxidant enzymes,and capacity of total antioxidant between the offspring with paternal metabolic syndrome （MS） and offspring with healthy father,and to provide evidence for obese prevention.Methods The case-control study design was utilized.There were 30 offspring with MS in case group,and 74 offspring with healthy father in control group.The height,weight,waist circumference,and blood pressure （BP） were measured,the body mass index （BMI）,the waist-to-height ratio （WHtR） and the waist-to-hip（WHR） were calculated.The FPG,TC,TG,HDL-C,LDL-C,activities of superoxide dismutase （SOD）,glutathione peroxidase （GSH-PX）,total antioxidant capacity （TAOC） were detected.Results Two sets of offspring MS components（WC,DBP,WHR,WHtR）and low level of HDL-C were significant higher in case group than in control（P0.05）but the activities of SOD and GSH-PX was lower than the control（P0.01）.The activities of SOD and GSH-PX were negatively correlated with WC,WHtR,WHR and DBP（P0.05）but positively correlated with HDL-C（P0.05）.Conclusion The rates of MS and MS-related components in adolescents with paternal MS are significantly higher and antioxidant enzyme activity is lower than those in control group with healthy father.The antioxidant enzyme activity is significantly correlated with obesity and dyslipidemia of MS components.