基因芯片技术在缺血性脑损伤研究中的应用

Application of Gene Chip in Ischemic Brain Damage

为了解基因芯片技术在各种缺血性脑损伤研究中的应用现状,探讨其应用价值及前景,通过检索MEDLINE、EMBASE、CNKI、维普等相关中英文数据库,查阅关于基因芯片技术在各种缺血性脑损伤中应用的相关文献并进行整理分析。文献资料表明基因芯片技术在包括全脑缺血、局灶性脑缺血及缺氧缺血等脑损伤研究的运用中,发现了许多脑损伤后的差异表达基因,其中包括损伤病理机制中的重要调节基因及具有神经保护作用的新基因等。证实基因芯片技术在缺血性脑损伤研究中具有巨大的应用价值。

To understand the present application of gene chip in ischemic brain damage,investigate the application value and the future trends of gene chip technology,the literatures on the application of gene chip in the research of all kinds of ischemic brain damage in the database including MEDLINE,EMBASE,CNKI and VIP were reviewed and comprehensively analyzed.Literatures showed that many differential expressed genes including the significant regulating genes in the pathomechanism and some new neuroprotective genes were found during the application in the research of brain damage including global ischemia,focal cerebral ischemia,and hypoxic ischemic brain damage.Therefore,gene chip has manifested its great application value in the research of ischemic brain damage and deserves a further investigation.