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3-去氮腺苷对脐静脉内皮细胞超氧化物歧化酶表达及甲基化的影响

Effects of 3-Deazaadenosine on Superoxide Dismutase Expression and Methylation in Human Umbilical Venous Endothlial Cells
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摘要 既往研究显示,高蛋氨酸摄入和B族维生素缺乏等膳食因素、以及先天性蛋氨酸代谢酶缺失等均可导致血浆中总同型半胱氨酸（total homocysteine．tHcy）升高，从而迎同升向。一脉苷同型半胱氨酸（s-adenosylhomocysteine，SAH）水平，影响机体正常甲基化。
作者 余小平 凌文华
机构地区 成都医学院公共卫生学教研室 中山大学公共卫生学院营养系
出处 《营养学报》 CAS CSCD 北大核心 2010年第3期304-305,308,共3页 Acta Nutrimenta Sinica
基金 国家自然科学基金(No.30571568 30771794) 教育部新世纪优秀人才支持计划(No.NCET-08-0901) 教育部科学技术研究重点项目(No.208123) 四川省青年科技基金(No.09ZQ026-036)
关键词 3-去氮腺苷 人脐静脉内皮细胞 超氧化物歧化酶 甲基化 3-deazaadenosine （DZA） human umbilical vein endothelial cell （HUVEC） superoxide dismutase （SOD） methylation
分类号 R151 [医药卫生—营养与食品卫生学]
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参考文献7

  • 1Zaina S, Lindholm MW, Lund G. Nutrition and aberrant DNA methylationpatterns inatheroselerosis: more than just hyperhomocysteinemia? JNutr, 2005, 135: 5-8.
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  • 3余小平,刘驰,夏敏,王庆,迟东升,凌文华.S-腺苷同型半胱氨酸升高与人脐静脉内皮细胞损伤及整体基因组甲基化的关系分析[J].营养学报,2007,29(6):547-551. 被引量：6
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二级参考文献20

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营养学报
2010年 第3期

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