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NO-ASA与肿瘤防护

NO-ASA and tumor chemoprevention
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摘要 NO-ASA(nitric-oxide-donating acetylsalicylic acid)是一种新的肿瘤防护药物,由ASA和-ONO2过空间臂相连而成。NO-ASA克服了ASA的低剂量耐受和毒副作用。研究显示NO-ASA抑制多种癌细胞的生长,抑制作用明显强于传统的ASA。NO-ASA极可能是一种预防和治疗肿瘤的有效药物。 Nitric-oxide-donating aspirin（NO-ASA）,consisting of ASA（aspirin） plus an-ONO2 moiety linked to it via a molecular spacer,is a new drug for cancer prevention.NO-ASA seems to overcome the low potency and toxicity of traditional ASA.NO-ASA inhibited the growth of some human cancer cell lines.NO-ASA is a highly promising agent for the prevention and/or treatment of cancer.
作者 魏丽丽 王中堂 宋现让
机构地区 山东省肿瘤医院检验科 山东省肿瘤医院放射六科
出处 《生命的化学》 CAS CSCD 北大核心 2010年第3期401-404,共4页 Chemistry of Life
关键词 NO-ASA 肿瘤 肿瘤防护 NO-ASA tumor chemoprevention
分类号 R73-36 [医药卫生—肿瘤]
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参考文献18

  • 1Rigas B et al. Nitric-oxide-donating NSAIDs as agents for cancer prevention. Trends Mol Med, 2004, 10:324-330.
  • 2Baron JA et al. A randomized trial of aspirin to prevent colorectal adenomas. N Engl J Med, 2003, 348:891-899.
  • 3Yeh RK et al. NO-donating nonsteroidal antiinflammatory drugs (NSAIDs) inhibit colon cancer cell growth more potently than traditional NSAIDs: a general pharmacological property? Biochem Pharmacol, 2004,67:2197-2205.
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  • 5Nath Net al. Nitric oxide-donating aspirin inhibits β-catenin- T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear 13-catenin-TCF association. Proc Natl Acad Sci USA, 2003,100:12584-12589.
  • 6Lu W et al. Suppression of Wnt/β-catenin signaling inhibits prostate cancer cell proliferation. Eur J Pharmacol, 2009,602:8-14.
  • 7Nath Net al. Nitro-aspirin inhibits MCF-7 breast cancer cell growth: effects on COX-2 expression and Wnt/β-catenin/ TCF-4 signaling. Biochem Pharmacol, 2009, 78:1298-1304.
  • 8Williams JL et al. Growth inhibition of human colon cancer cells by nitric oxide (NO)-donating aspirin is associated with cyclooxygenase-2 induction and β-catenin/T-cell factor signaling, nuclear factor-γB, and NO synthase 2 inhibition: implications for chemoprevention. Cancer Res, 2003, 63: 7613-7618.
  • 9Spiegel A et al. NO-donating aspirin inhibits both the expression and catalytic activity of inducible nitric oxide synthase in HT-29 human colon cancer cells. Biochem Pharmacol, 2005, 70:993-1000.
  • 10Williams JL et al. NO-donating aspirin inhibits the activation of NF-kB in human cancer cell lines and Min mice. Carcinogenesis, 2008, 29:390-397.
生命的化学
2010年 第3期

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