肿瘤对树突状细胞功能的影响

Impact of tumor on the functions of dendritic cell

树突状细胞(DC)是专职的抗原提呈细胞,能浸润很多种肿瘤,并获取、处理、并提呈肿瘤相关抗原给T细胞,诱导特异性抗肿瘤免疫反应。但在肿瘤微环境中,存在一系列瘤源性抑制因子,这些因子对DC的发育成熟都有直接或间接的抑制作用,癌症患者体内外周血循环中的DC和浸润到肿瘤中的DC都受到这种作用的影响而存在表型和功能的缺陷。已经证明,导致DC缺陷的几种肿瘤来源的因子有VEGF、IL-6、IL-10、M-CSF等。进一步深入了解DC分化缺陷的主要因素有助于发展更有效的抗癌免疫治疗策略。

Dendritic cells（DCs） are professional antigen presenting cells and have been shown to infiltrate many tumors.They acquire,process,and present tumor-associated antigens to T cells.Several tumor-derived factors have direct or indirect inhibition of the development and maturation of DCs.Circulating and tumor-infiltrating DCs appear to be phenotypically and functionally defective.Tumor-derived factors such as VEGF,IL-6,IL-10,and M-CSF,have been shown to be responsible for systemic and local DC defects in tumor microenvironment.Further understanding of the main factors of DC differentiation defects is helpful for developing more effective anti-cancer immunotherapy strategies.