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胎盘特异性基因PLAC1与肿瘤 被引量：1

Placenta-specific gene PLAC1 and tumor
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摘要 胎盘特异性基因PLAC1(placenta-specific 1 gene)具有癌-睾丸(cancer-testis antigen,CT)抗原的特点,即能在多种肿瘤组织中表达,而在正常组织(除胎盘和睾丸)几乎不表达。PLAC1编码一种膜蛋白,该蛋白质具有一定的免疫原性,能在肿瘤患者体内引起体液免疫和细胞免疫。目前的研究结果显示PLAC1代表一类新的肿瘤相关抗原,可能成为肿瘤免疫治疗的一个靶点。 Placenta-specific gene PLAC1 is characterized by cancer-testis antigen,which is frequently expressed in different types of tumors while it is hardly expressed in normal tissues（except for placenta and testis）.PLAC1 encodes a membrane protein that is immunogenic and is capable of eliciting immune responses in tumor patients.The current results reveal that PLAC1 represents a new class of tumor associated antigen and it is a promising target for tumor immunotherapy.
作者 闫光华 罗彬 肖绍文 谢小薰
机构地区 广西医科大学组织学与胚胎学教研室
出处 《生命的化学》 CAS CSCD 北大核心 2010年第3期459-463,共5页 Chemistry of Life
基金 国家自然科学基金资助项目(No.30760055) 广西教育厅研究生教育创新计划项目(No.2009105981001M190) 广西高发疾病研究创新性团队基金资助项目(No.桂教人[2007-59]号)资助
关键词 PLAC1 胎盘特异性基因 肿瘤免疫治疗 PLAC1 placenta-specific gene tumor immunotherapy
分类号 R730.2 [医药卫生—肿瘤]
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参考文献24

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二级参考文献9

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生命的化学
2010年 第3期

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