骨桥蛋白与肝脏发育、肝再生及肝脏疾病

Roles of osteopontin in liver development,regeneration and liver diseases

骨桥蛋白(osteopontin,OPN)是一种分泌型磷酸化糖蛋白,结构上与多种胞外基质蛋白相似,功能上具有细胞因子的特点,在多种生理、病理过程中发挥重要作用。在肝中,它可能参与肝脏发育和肝再生,并与急性肝炎、脂肪性肝炎、肝纤维化及肝癌等疾病的发生、发展密切相关。本文综述了OPN在肝脏发育、肝再生和肝脏疾病等中的作用研究进展,为开展OPN在促进肝再生及肝脏疾病诊断、治疗方面的应用提供重要理论基础。

Osteopontin（OPN） is a highly modified secretory glycol-phosphoprotein.It is structurally similar to a variety of matrix proteins,and shares the functional properties of cytokines and is involved in diverse physiological and pathological processes.Recent evidence indicates that OPN may be involved in liver development and regeneration and is closely related with liver diseases,such as acute hepatitis,alcoholic or nonalcoholic steatohepatitis,liver fibrosis,and hepatocellular carcinoma.Here we reviewed research progress of the complex roles of OPN in liver development,regeneration and liver diseases,and laid an important theoretical foundation for application of OPN in promotion of liver regeneration and diagnosis,treatment of liver diseases.