三相相转移催化剂催化合成N-乙基间甲苯胺的研究

Performance of Triphase Catalysis in the Synthesis of N-ethyl-m-toluidine

采用三相相转移催化剂(四丁基溴化铵-聚苯乙烯树脂),催化间甲苯胺与溴乙烷合成N-乙基间甲苯胺的新工艺,探讨了合成反应条件对N-乙基间甲苯胺收率的影响,在催化剂用量4.4％、间甲苯胺与溴乙烷摩尔比为1:1.6的优化条件下,N-乙基间甲苯胺的收率达到93.6％。

A new process has been developed to synthesize N-ethyl-m-toluidine from m-toluidine and bromoethane by catalysis of triphase transfer catalyst (TBAT-PS) and a study of the effect of reaction conditions on the yield of N-ethyl-m-toluidine was also conducted.The yield of N-ethyl-m-toluidine was 93.6% under the optimum reaction conditions, i.e.the consumption of catalyst was 4.4 %, the molar ratio of m-toluidine to bromoethane was 1:1.6, and the reaction time was 6 h.