摘要
目的 探讨磷酸化哺乳动物雷帕霉素靶蛋白(p-mTOR)在良恶性子宫内膜病变组织中的表达情况.方法 应用免疫组化SP法检测45例子宫内膜样腺癌、7例子宫内膜非典型增生、6例增殖期子宫内膜组织中p-mTOR的表达情况.结果 p-mTOR主要分布于细胞质,在增殖期子宫内膜中呈弱阳性表达或阴性表达,蛋白颗粒密度为2.36±0.76 在子宫内膜非典型增生和子宫内膜样腺癌中高表达,蛋白颗粒密度分别为6.21±1.19、15.82±2.64,三者间比较差异有统计学意义(F=11.37,P<0.05).在子宫内膜样腺癌组织中,不同组织学分级p-mTOR表达差异有统计学意义(F=8.27,P<0.05),但不同病理分期p-mTOR表达差异无统计学意义(P>0.05).结论 p-mTOR可能参与了子宫内膜癌的发生和发展过程.
Objective To investigate the expression of phosphorylation-mammalian target of rapamycin (p-mTOR) in endometrial carcinoma. Methods The expressions of p-mTOR protein in tissues from 45 cases of endometrial adenocarcinoma, 7 endometrial atypical hyperplasia, and 6 normal endometrium were detected by immunohistochemistry SP method. Results The expression of p-mTOR protein maily restricted to cytoplasm. Compared with normal endometrium, the expression of p-mTOR protein in the cases of endometrial atypical hyperplasia and endometrial adenocarcinoma was significantly up-regulation(2.36 ± 0.76vs 6.21 ± 1.19, 15.82 ± 2.64)( F = 11.37, P 〈 0.05 ). There was significant difference of p-mTOR protein in different histology class in endometrial adenocarcinoma (F = 8.27, P 〈 0.05), but there was no significant difference of p-mTOR protein in different pathological grade in endometrial adenocarcinoma (P 〉0.05).Conclusion The expression of p-mTOR protein may participate in the occurrence and development of endometrial carcinoma.
出处
《中国医师进修杂志》
2010年第18期21-23,共3页
Chinese Journal of Postgraduates of Medicine