肺功能及过敏原检测在儿童咳嗽变异型哮喘诊断中的临床意义

Clinical significance of lung function and allergen detection in children with cough variant asthma diagnosis

目的 探讨肺功能及过敏原检测在儿童咳嗽变异型哮喘（CVA）诊断中的临床意义.方法 对43例慢性咳嗽患儿支气管激发（舒张）试验及过敏原皮试点刺试验结果进行分析,其中CVA组（确诊为CVA的患儿）23例和对照组（其他慢性咳嗽患儿）20例.结果 CVA组支气管激发（舒张）试验阳性19例,对照组3例,差异有统计学意义（x2=14.745,P＜0.01） CVA组过敏原皮试点刺试验阳性17例,对照组5例,差异有统计学意义（x2=10.243,P＜0.05） 支气管激发（舒张）试验与过敏原皮试点刺试验结果呈显著正相关（r=0.404,P＜0.01）.结论 支气管激发（舒张）试验对CVA的诊断具有重要作用 过敏原皮试点刺试验对CVA诊断有辅助作用 过敏原对肺功能有影响,支气管激发（舒张）试验配合过敏原皮试点刺试验有助于儿童CVA的早期诊断.

Objective To study the clinical significance of lung function and allergen detection in the diagnosis of cough variant asthma （CVA） in children. Method Forty-three cases of chronic cough in children with bronchial provocation （diastolic） test and skin prick allergy test results were analyzed, CVA group was 23 cases and control group was 20 cases. Results The positive of bronchial provocation （diastolic） test in CVA group was 19 cases, significantly higher than that in control group （3 cases, χ2=14.745, P 〈 0.01 ）.The positive of skin prick allergy test in CVA group was 17 cases , significantly higher than that in control group （5 cases, χ2 = 10.243,P 〈0.05）. The correlation analysis showed that bronchial provocation （diastolic） test and skin prick allergy test was significantly correlated （r =0.404,P〈0.01 ）.Conclusion Bronchial provocation （diastolic） test has an important role in the diagnosis of CVA skin prick allergy test has a supporting role on the CVA diagnosis allergens affect on lung function, bronchial provocation （diastolic） test with the help of skin prick allergy test in children with cough variant asthma diagnosis.