40Hz听性稳态反应在脑干卒中患者中的近期预后价值

Short-term prognostic value of the 40 Hz auditory steady state response in patients with brainstem stroke

目的探讨40Hz听性稳态反应（40Hz auditory steady state response，40-Hz ASSR）在脑干卒中患者近期预后评价中的价值。方法分别对神经重症监护病房（Neurological Intensive Care Unit，NICU）收治的36例脑干卒中患者进行40-HzASSR和脑干听觉诱发电位（brainstem auditory evoked potential，BAEP）检查，并对两者进行分级。以转出NICU时为近期预后评价终点，将脑干卒中患者分为生存组（n=21）和死亡组（包括脑死亡，n=15），分析40-HzASSR和BAEP分级与近期预后的相关性。结果40-HZAssR（r=0．571，P=0．000）、BAEP（r=0．441，P=0．001）分级与脑干卒中患者近期预后显著相关。40-HzASSR的敏感性、特异性和准确性分别为60．00％、100％和83．33％，而BAEP分级则分别为66．67％、71．43％和69．44％。结论40-HzASSR对脑干卒中患者的近期预后有一定的预测价值；级别越高提示病情越严重，预后也越差。

Objective To investigate the predictive value of the 40 Hz auditory steady state response （40-Hz ASSR） in the short-term prognosis of patients with brainstem stroke. Methods The 40-Hz ASSR and brainstem auditory evoked potentials （BAEP） examinations were recorded and graded from 36 patients with brainstem stroke admitted in the Neurological Intensive Care Unit （NICU）. The end point of short-term prognostic evaluation was at the time of leaving the NICU. The patients with brainstem stroke were divided into the survival group （n = 21 ） and the death group （including brain death, n = 15）. The correlation between the grade of the 40-Hz ASSR or BAEP and the short-term prognosis was analyzed. Results The grade of the 40-Hz ASSR （r =0. 571, P =0.000） or BAEP （r =0. 441, P =0. 001） was significantly correlated with the short-term prognosis in patients with brainstem stroke. The sensitivity, specificity and accuracy of the 40-Hz ASSR were 60.00%, 100% and 83.33%, respectively, and those for BAEP were 66.67%, 71.43% and 69.44%, respectively. Conclusions The 40- Hz ASSR has a certain short-term prognostic value in patients with brainstem stroke. The higher the grade of 40-Hz ASSR is, the more serious the illness, and the worse the prognosis.