氟比洛芬酯对下肢骨折术后镇痛的临床观察

Therapeutic Effect of Flurbiprofen Axetil Injection for the Treatment of Pain after Lower Limb Fracture

目的观察氟比洛芬酯对下肢骨折术后镇痛的临床疗效。方法 92例下肢骨折术后患者采用完全随机方法分为A、B两组,A组给予氟比洛芬酯注射液50mg静脉推注,B组给予曲马多注射液100mg肌内注射,观察指标为镇痛效果、起效时间、持续时间及不良反应。结果各时点镇痛效果VAS评分A组低于B组(P<0.05)。A组镇痛起效时间(8.36±5.89)min,B组镇痛起效时间(16.67±8.95)min,两组差异有显著性(P<0.05)。镇痛持续时间4h以上两组均达56.5%,两组差异无显著性(P>0.05)。两组的不良反应发生率差异无显著性(P>0.05)。结论氟比洛芬酯可为下肢骨折术后提供良好的镇痛效果且副作用少。

Objective To observe the efficacy of nurbiprofen axetil injection after lower limb fracture. Methods 92 cases of lower limb fracture were randomly divided into group A and B. The flurbiprofen axetil in- jection 50 mg were given by intravenous injection in group A. The tramadol injection 100 mg were given by intra- muscular injection in group B. The analgesic effect, onset time, duration time and adverse reactions of drugs were observed comparatively between two groups. Results The VAS of group A was lower than that of group B （P 〈 0. 05 ）, analgesia time of group A and B were （ 8.36 ± 5.89 ） min and （ 16. 67 ±8.95 ） min respectively, there were significant difference between two groups. Both groups have over 4 hours duration time with the same percentage of 56. 5% ,the incidence of adverse reactions had no difference between group A and B（ P 〉 0. 05 ）. Conclusion Flurbiprofen axetil injection for the treatment of pain after lower limb fracture has a good postoperative analgesic effect and less adverse reactions.