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阿利吉仑及其临床研究概况 被引量：1

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摘要 阿利吉仑(aliskiren)是由诺华制药公司首创的新型口服低分子量非肽类肾素抑制剂,它作用于RAS的第一限速步骤,不同于ACEI及ARB;它不含肽链不引起含肽链的其他肾素抑制剂所产生的不良反应。是首个合成的新型非肽类肾素抑制剂。是一种治疗肾素型高血压、安全、有效的口服新药。
作者 刘雯静 金仲品
机构地区 山东省滨州市邹平县医院药剂科 滨州职业学院
出处 《中国实用医药》 2010年第18期233-234,共2页 China Practical Medicine
关键词 阿利吉仑 肾素抑制剂 肾素型高血压
分类号 R96 [医药卫生—药理学]
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参考文献16

  • 1Dubois EA,Cohen AF.Aliskire.Br J Clin Pharmacol,2009,68(5):653-654.
  • 2Dzau V.The cardiovascular continuum and resin-angiotensin-aldosterone system blockade.J Hypextens Suppl,2005,23(1):S9-S17.
  • 3O'Brien E,Barton J,Nussberger J,et al.Aliskiren reduces blood pressure and suppresses plasma renin activity in combination with a thiazide diuretic,an angiotensin-converting enzyme,or an angiotensin receptor receptor blocker.Hypertension,2007,49(2):276-284.
  • 4Dalla Vestra M,Simioni N,Masiero A.Aliskiren:a new inhibitor of renin-an-giotensin aldosterone system activity.Minerva Endocrinol,2009,34(4):333-338.
  • 5Azizi Nl,Menard J,Bissery A,et al.Pharmacologic demonstration of the synergistic effects of a combination of the resin inhibitor vliskiren and the ATl receptor antagonist valsartan on the angiotcnsinⅡ-resin feedback interruption.J Am Son Nephrol,2004,15(12):3126-3133.
  • 6Vaidvanathan S,Warren V,Yeh C,et al.Pharmacokinetics,safety,and tolerability of the oral Renin inhibitor aliskiren in patients with hepatic impairmeny.J Clin Pharmacol,2007,47(2):192-200.
  • 7Dieterle W,Corynen S,Mann J.Effect of the oral renin inhibitor aliskiren on the pharmac:okinetics and pharmacodynamics of a single dose of watfarin in healthy aubjects.Br J Clin Pharmaoal,2004,58(4):433-436.
  • 8Hollenberg VK.AngintensinⅡsuppression in humans by the orally active renin inhibitor aliskiren (SPP100).Comparison with enalaluil.Curr Hypertcns Rcp,2004,6(4):269-270.
  • 9Wood JM,Schnell CR,Cumin P,et al.Aliskiren,a novel,orally effective renin inhihitor,lowers blood pressure in mar mosets and spontaneously hypertensive rats.J Hypertens,2005,23(2):417-426.
  • 10Gradman AH,Sghmieder RE,Lins RL,et al.Aliskiren a novel orally effective renin inhibitor,provides close-dependent antihypertensive effioacy and placebo-like tolerability in hypertensive patients.Circulation,2005,111 (8):1012-1018.

同被引文献25

  • 1Y. F. Dong,L. Liu,K. Kataoka,T. Nakamura,M. Fukuda,Y. Tokutomi,H. Nako,H. Ogawa,S. Kim-Mitsuyama.Aliskiren prevents cardiovascular complications and pancreatic injury in a mouse model of obesity and type 2 diabetes[J]. Diabetologia . 2010 (1)
  • 2Stanton A,Jensen C,Nussberger J,et al.Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren. Journal of Hypertension . 2003
  • 3Pimenta E,,Oparil S.Role of aliskiren in cardiorenal protection and use in hypertensives with multiple risk factors. Vasc Health Risk Manag . 2009
  • 4AZIZI M,MENARD J,BISSERY A,et al.Pharmacologic dem-onstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1receptor antagonist valsartan on the angiotensin II-renin feedback interruption. Journal of the American Society of Nephrology . 2004
  • 5JH Esch,E Moltzer,R Veghel,IM Garrelds,F Leijten,AM Bouhuizen.Beneficial cardiac effects of the renin inhibitor aliskiren in spontaneously hypertensive rats. Journal of Hypertension . 2010
  • 6Ye Y,Qian J,Castillo AC,et al.Aliskiren and ValsartanReduce Myo-cardial AT1Receptor Expression and Limit Myo-cardial Infarct Size in Diabetic Mice. Cardiovascular Drugs and Therapy . 2011
  • 7Yamamoto E,Kataoka K,Dong YF,et al.Aliskiren enhances the protective effects of valsartan against cardiovascular and renal injury in endothelial nitric oxide synthase-deficient mice. Journal of Hypertension . 2009
  • 8Solomon S D,Appelbaum E,Manning W J, et al.Effect of the Direct Renin Inhibitor Aliskiren, the Angiotensin Receptor Blocker Losartan, or Both on Left Ventricular Mass in Patients With Hypertension and Left VentricularHypertrophy. Circulation . 2009
  • 9Lu,H.,Rateri,D.L.,Feldman,D.L.,Jr,R.J.,Fukamizu,A.,Ishida,J.,Oesterling,E.G,Cassis,L.A.,Daugherty,A.Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice. The Journal of Clinical Investigation . 2008
  • 10Verdecchia P,Angeli F,Mazzotta G,Gentile G,Reboldi G.The renin angiotensin system in the development of cardiovascular disease: role of aliskiren in risk reduction. Vasc Health Risk Manag . 2008

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中国实用医药
2010年 第18期

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