环境内分泌干扰物快速筛选方法研究进展

Progress in the Rapid Screening of Endocrine Disrupting Chemicals

为了减少和避免自然界中日益增多的环境内分泌干扰物对生物体及人类的危害,建立方便、有效、快捷的筛选方法,以从环境污染物中检测出具有潜在的干扰内分泌系统的化学物质等已成为环境科学的热点研究方向。本文从4个研究层面分类综述了近年来环境内分泌干扰物快速筛选方法的研究进展,分析了各类筛选方法的优缺点,展望了其发展前景。

Endocrine Disrupting Chemicals（EDCs） are exogenous substances that act like hormones in the endocrine system and disrupt the physiologic functions of endogenous hormones.They are sometimes also referred to as endocrine disruptors,or hormonally active agents.EDCs encompass a variety of chemical classes,including hormones,plant constituents,pesticides,compounds used in the plastics industry and in consumer products,and other industrial by-products and pollutants.With the industrial development,more and more EDCs are pervaded and widely dispersed in the environment,and the exposure to EDCs poses ever greater threat.Therefore,it becomes a top priority to reduce or avoid the increasing exposure of organisms or even human beings to EDCs.In the research field of environmental sciences,the establishment of a most convenient,efficient and effective screening method to detect chemicals with the potential to interfere with the endocrine hormone levels from pollutants is a hot project.This paper reviews the recent progress on rapid methods for detecting EDCs in the environment,and these mature rapid screening methods are grouped into four categories.Advantages and disadvantages in theory and practice of these methods are analyzed.The development prospects and strategy are also discussed.