重症监护病房深部假丝酵母菌属感染耐药性分析

Drug resistance of deep Candidal infection in intensive care unit

目的:探讨重症监护病房(ICU)深部假丝酵母菌属感染的菌种分布特点及耐药性,指导临床合理用药。方法:采用ATB-FUNGUS 3药敏自动分析系统对ICU分离的假丝酵母菌属进行药物敏感性试验。结果:检出假丝酵母菌属103株,其中白色假丝酵母菌检出率最高(63.1%);其次为热带假丝酵母菌(19.4%)。假丝酵母菌属对两性霉素B、5-氟胞嘧啶、伏立康唑、氟康唑、依曲康唑耐药率分别为1.9%、3.9%、10.7%、11.7%、23.3%。结论:ICU患者深部假丝酵母菌属感染以白色假丝酵母菌为主,药敏结果显示对依曲康唑耐药率最高,对两性霉素B耐药率最低。临床应根据药敏试验结果合理使用抗真菌药物。

Objective：To investigate the distribution of Candida species and drug resistance of deep Candidal infection in intensive care unit（ICU） in order to provide help to clinics.Methods：The susceptibility test perform by ATB Fungus 3 automatic analysis system.Results：Totally 103 strains of Candida were detected in ICU.The C.albicans was the most commonly isolated species（63.1%） and then was C.tropicalis（19.4%） in all Candida species.The resistance rate to amphotericin B,5-fluorocytosine,voriconazole,fluconazole,itraconazole was 1.9%,3.9%,10.7%,11.7%,23.3%,respectively.Conclusion：C.albicans is the most commom pathogen of Candidal infection in ICU.The highest resistance to itraconazole and the lowest resistance to amphotericin B.Clinics should use antifungal drug rationally in accordance with drug susceptibility test results.