浙江地区畲族和汉族健康人群ACE基因多态性分布的研究

Polymorphism studies on angiotensin I-converting enzyme gene (ACE) in Chinese She and Chinese Han People in Zhejiang

目的:了解浙江地区畲族和汉族人群血管紧张素转换酶(ACE)基因插入/缺失多态性分布情况。方法:采用聚合酶链反应(PCR)分别检测201例畲族和204例汉族健康人群ACE基因插入/缺失(I/D)多态性,分类计数并进行统计学分析。结果:畲族人群的II型、DI型和DD型频率分别为25.9%,32.8%和41.3%;汉族人群的II型、DI型和DD型频率分别为45.1%,41.2%和13.7%。结论:ACE基因多态性的分布与性别无关,ACE基因多态性在浙江地区畲族和汉族人群中的分布存在差异性。

Objective：To find out the gene polymorphism of angiotensin I-converting enzyme（ACE） in healthy population of Chinese She and Chinese Han people in Zhejiang area.Methods：The PCR was used to detect the insert or defect（I/D） gene polymorphism of ACE in 201 Chinese She and 204 Chinese Han people in Zhejiang area.The results were differential counted and analyzed with statistical software.Results：The frequency of II,ID and DD type is 25.9%,32.8% and 41.3% respectively in Chinese She people,and the frequency is 45.1%,41.2% and 13.7% in Chinese Han people respectively.Conclusion：The distribution of gene polymorphism of ACE is unrelated to sex,and there are differences in the distribution of gene polymorphism of ACE between Chinese She and Han people in Zhejiang area.