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Klotho基因及其多态性的研究进展 被引量：1

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作者 孟庆玲 黄曙 范志宁
机构地区 南京浦口医院消化内科 南京医科大学第二附属医院消化医学中心
出处 《中国老年学杂志》 CAS CSCD 北大核心 2010年第12期1768-1770,共3页 Chinese Journal of Gerontology
基金 南京医科大学校基金重点项目(No.07NMUZ015)
关键词 KLOTHO基因 多态性 研究进展
分类号 R575 [医药卫生—消化系统]
  • 相关文献

参考文献30

  • 1Kuro-o M,Matsumura Y,Aizawa H,et al.Mutation of the mouse klotho gene leads to a syndrome resembling aging[J].Nature,1997;390:45-51.
  • 2Matsumura Y,Aizawa H,Shiraki-Iida T,et al.Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein[J].Biochem Biophys Res Commun,1998;243(3):626-30.
  • 3Saito Y,Kuro-o M,Nabeshima Y,et al.The protective role of klotho gene on vascular endothelium[J].Nippon Rinsho,1999;57(7):1514-8.
  • 4Shiraki-Iida T,Aizawa H,Matsumura Y,et al.Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein[J].FEBS Lett,1998;424(1-2):6-10.
  • 5Arking DE,Krebsovs A,Macek M Sr,et al.Association of human aging with a functional variant of klotho[J].Proc Natl Acad Sci USA,2002;99:856-61.
  • 6Low AF,O′Donnel CJ,Kathiresan S,et al.Aging sysdrome genes and premature coronary artery disease[J].BMC Med Genet,2005;6:38-46.
  • 7Kim Y,Kim JH,Nam YJ,et al.Klotho is a genetic risk factor for ischemic stroke caused by cardioembolism in Korean females[J].Neurosci Lett,2006;407(3):189-194.
  • 8Kawano K,Ogata N,Chiano M,et al.Klotho gene polymorphisms associated with bone density of aged postmenopausal women[J].J Bone Miner Res,2002;17:1744-51.
  • 9Imamura A,Okumura K,Ogawa Y,et al.Klotho gene polymorphism may be a genetic risk factor for atherosclerotic coronary artery disease but not for vasospastic angina in Japanese[J].Clin Chim Acta,2006;371:66-70.
  • 10Riancho JA,Valero C,Hernandez JL,et al.Association of the F352V variant of the klotho gene with bone mineral density[J].Biogerontology,2007;8:121-7.

二级参考文献17

  • 1Kelley JR,Duggan JM. Gastric cancer epidemiology and risk factors [ J 1. J Clin Epidemiol, 2003,56( 1 ) :1-9
  • 2Reddy BS,Wang CX,Kong AN,et al. Pevention of azoxymethane-induced colon cancer by combination of low doses of atorvastatin aspirin and celecoxib in F344 rats [ J ], Cancer Res, 2006,66 (8), 4542-4546
  • 3Kuro-o M, Matsumura Y, Aizawa H, et al. Mutation of the mouse klotho gene leads to a syndrome resembling aging [ J ]. Nature, 1997,390:45-51
  • 4Yamamoto M, Clark JD, Pastor JV, et al. Regulation of oxidative stress by the anti-aging hormone klotho[J]. J Biol Chem, 2005,280: 38029-38034
  • 5D.E. Arking, A. Krebsovs,M. Macek Sr et al. Association of human aging with a functional variant of klotho [J]. Proc Natl Acad Sci USA, 2002,99 : 856-861
  • 6AFLow, CJO, Donnel, S Kathiresan, et al. Aging sysdrome genes and premature coronary artery disease [J]. BMC tied Genet, 2005,6: 38-46
  • 7Kim Y,Kim JH,Nam YJ,et al. Klotho is a genetic risk factor for isehemie stroke caused by cardioembolism in Korean females[J]. Neurosci Lett,2006,407(3) : 189-194
  • 8Kawano K,Ogata N,Chiano M,et al. Klotho gene polymorphisms associated with bone density of aged postmenopausal women [J]. J Bone Miner Res,2002,17: 1744-1751
  • 9Rhee EJ,Oh KW,Yun EJ,et al. Relationship between polymorphisms G395A in promoter and C1818T in exon 4 of the KLOTHO gene with glucose metabolism and cardiovascular risk factors in Korean women [J]. J Endocrinol Invest, 2006,29: 613-618
  • 10Lu L,Katsaros D,Wiley A,et al. Klotho expression in epithelial ovarian cancer and its association with insulin-like growth factors and disease progression[J]. Cancer Invest, 2008,26(2) : 185-92

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中国老年学杂志
2010年 第12期

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