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致敏患者肾移植的处理策略 被引量:1

Pretreatment strategies in sensitized recipients for kidney transplantation
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摘要 随着肾移植例数的增长,近年来国内外各大移植中心的移植物功能丧失及致敏受者也迅速增多.2007年美国器官获取及移植网络(OPTN)和器官移植受体科学登记处(SRTR)的年报显示,在等待肾移植的患者中高致敏患者(群体反应性抗体≥80%)占15.8%.体内预存的高水平的抗HLA抗体不仅可诱发各种类型的排斥反应、延缓移植物功能恢复,而且还与移植物功能丧失相关.目前,对致敏受者的临床处理尚缺乏公认的理想措施,本文就有关问题进行探讨,以期为致敏受者的肾移植提供借鉴.
作者 张伟杰
出处 《中华器官移植杂志》 CAS CSCD 北大核心 2010年第6期325-327,共3页 Chinese Journal of Organ Transplantation
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参考文献18

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同被引文献9

  • 1Vo AA, Lukovsky M, Toyoda M, et al. Rituximab and intravenous immune globulin for desensitization during renal transplantation. N Engl J Med, 2008, 359(3):242-251.
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  • 4Jordan SC, Reinsmoen N, Lai CH, et al. Novel immunotherapeutic approaches to improve rates and Outcomes of transplantation in sensitized renal allograft recipients. Discov Med, 2012, 13(70) : 235-245.
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  • 8ZhangW, Chen D, Chen Z, et al. Successful kidney transplantation in highly sensitized patients. Front Med, 2011, 5(1):80-85.
  • 9孙启全.移植肾急性体液性排斥的个体化治疗[J].肾脏病与透析肾移植杂志,2009,18(5):442-443. 被引量:1

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