含甘油与芝麻油制剂治疗干性皮肤功效对比分析

Clinical evaluation of glycerin and sesame oil praeparatum in treatment of xerosis

目的 评价含甘油与芝麻油制剂治疗干性皮肤的临床安全性与功效性.方法 随机选择干性皮肤患者的一肢体作为实验侧,外用含23.8%甘油制剂,每日2次;其对侧外用含43.7%芝麻油制剂,每日2次.观察期为14 d,分别于治疗前、治疗3、7、14 d,由患者和医师共同观察皮肤表现（粗糙度、干燥、鳞屑）.同时,检测皮肤角质层含水量和经皮肤失水参数.结果 共完成24例,男10例,女14例,平均年龄（29士9.6）岁.经治疗后实验侧与对照侧皮肤干燥,鳞屑均有不同程度改善;角质层含水量逐渐增加,经皮肤失水逐渐减少,且实验侧与对照侧两侧的差异均具有统计学意义（P〈0.01）;在实验过程中,所有患者均未出现不良反应.结论 含甘油与芝麻油制剂均能改善皮肤干燥状态,且甘油制剂功效明显优于芝麻油制剂.

Objective To evaluate the clinical efficacy and safety of praeparatum containing glycerin and sesame oil in treating dry skin patients. Methods one of patient＇s limbs was randomly selected to use praeparatum containing 23. 8 % glycerin twice a day, and the other side to use praeparatum containing 43. 7% sesame oil twice a day. During 14 days, the effects were observed and recorded when following-up at the days 0,3,7 and 14. Extent of drying was measured by evaluating each of the clinical symptoms （rough, drying and scale） and the following parameters were also evaluated： stratum corneum hydration （SCH） and trans-epidermal water loss （TEWL）. Results The clinical trial was completed in 24 xerosis patients, including 10 males and 14 females. The clinical scores for rough, drying and scale, were assessed by the patients and doctors, and both experimental and control groups were improved. Stratum corneum hydration was improved, trans-epidermal water loss was reduced, and both values had statistically significant difference （P〈0. 01）. There were no adverse reactions in all the patients during this experiment. Conclusions Both praeparatum containing glycerin and sesame oil could improve the condition of skin safely and effectively in xerosis patients, and the efficacy of glycerin praeparatum is better than sesame oil praeparatum.