喉原发性恶性淋巴瘤的临床特征分析

On the clinical features of primary laryngeal malignant lymphoma

目的总结喉部原发性恶性淋巴瘤的临床特征及其早期诊断程序。方法对本院1995～2003年间确诊的7例喉原发性恶性淋巴瘤患者的临床资料进行回顾性分析,总结本病的临床特征,探讨其早期诊断措施。结果主诉症状及影像学检查均无特异性;可以表现为声门上或声门区局限性或弥漫性肿物。活检1次确诊者仅1例,活检2次确诊者4例,活检3次确诊者2例。结论喉恶性淋巴瘤的临床表现和影像学检查无明显特异性,确诊常需要多次活检,并行免疫组化检查。

Objective To investigate the clinical features of primary laryngeal malignant lymphoma and the feasible procedures for its earlier diagnosis based on a clinical trial. Methods A retrospective study was carried out among 7 cases with primary laryngeal malignant lymphoma and treated in our Hospital during 1995 to 2003, with their clinical data analyzed carefully to sum up the clinical features and to explore the feasible procedures for the earlier diagnosis of this lesion. Results Generally speaking, no special clinical symptoms and image outcomes could be taken as the identical features for the diagnosis of such a lesion. This kind of lesion might manifest itself as a neoplasm, in a form either circumscribed or diffused growing, in glottic region or supraglottic area. In this group of cases, there were one finally diagnosed pathologically as such a condition with only once biopsy, four with two times biopsies, and two with their biopsy repeated three times to get a final diagnostic conclusion. Contusions There were no specific clinical manifestations and imaging features for the diagnosis of laryngeal malignant lymphoma. In generality, repeated biopsies are frequently needed to get a final diagnosis for such a condition, usually with immunohistochemical staining as an auxiliary procedure.