摘要
开发了4,4-二甲基噁唑烷-2-硫酮的新工艺:将2-氨基-2-甲基丙醇与二硫化碳加成的中间体溶于水,合成在水相中环合,可避免因二硫化碳的挥发而导致的吸入中毒,以及因过量的二硫化碳引起的杂质增加。通过在水中冷却结晶直接得到高纯度产品(99.3%),收率从40%提高到68%。
A new process for the preparation of 4,4-dimethyloxazolidine-2-thione was developed that the product from the condensation of 2-amino-2-methylpropanol with carbon disulfide was dissolved into water,followed by cyclization in aqueous NaOH solution.This technique avoided the toxic vaporous carbon disulfide and extra impurities.The product yield was increased from 40% to 68% with purity of 99.3%.
出处
《精细化工中间体》
CAS
2010年第3期32-33,43,共3页
Fine Chemical Intermediates
