缺氧诱导因子-1α在子宫内膜癌组织中的表达及其临床意义

Expression of Hypoxia Inducible Factor-1α in Endometrial Cancer Tissue and its Clinical Significance

目的探讨缺氧诱导因子1α在子宫内膜癌组织中的表达及其意义。方法用免疫组化法检测21例正常子宫内膜组织、29例不典型增生子宫内膜组织、44例子宫内膜癌组织中HIF-1α的表达情况,并分析其与子宫内膜癌临床病理特征的关系。结果 HIF-1α在子宫内膜癌和不典型增生子宫内膜组织中的阳性率明显高于正常子宫内膜组织(P<0.05)。在子宫内膜癌组织中HIF-1α阳性表达率与手术病理分期有关(P<0.05),但与肌层浸润、组织病理学分级、淋巴结转移无关(P>0.05)。在子宫内膜癌组织中HIF-1α阳性表达与雌激素受体呈正相关(P<0.01)。结论 HIF-1α的过表达参与了子宫内膜癌的发生、发展,HIF-1α和雌激素受体在子宫内膜癌中表达具有相关性。

Objective To explore the expression of hypoxia inducible factor-1 alpha（HIF-1α）in endometrial carcinoma tissue and its clinical significance.Methods Expression of HIF-1αwas determined immunohistochemically in 21 people with normal endometrium,29 patients with atypical hyperplasia and 44 patients with endometrial carcinoma.Analyzed the relationship between expression of HIF-1α and the clinical and pathological feature of endometrial cancer.Results The ratio of HIF-1α expressions in atypical endometrial hyperplasia and endometrial carcinoma were obviously higher than that in normal endometrium（P0.05）.The ratio of HIF-1α expression was related to the endometrial carcinoma clinical stage（P0.05）,but the pathological grade,muscular layer infiltration and lymph node metastasis had no obvious correlation with the expression of HIF-1α（P0.05）.The expression of HIF-1α was positive correlated with estrogen receptor（ER）in endometrial carcinoma（P0.05）.Conclusion The expression of HIF-1α may play an important role in the occurrence and development of endometrial carcinoma.The expression of HIF-1α is correlated with ER in endometrial carcinoma.