中性粒细胞/淋巴细胞比值在子宫内膜异位症中的临床意义初探

Pri mary Exploration of the Clinical Value of Neutrophil-to-lymphocyte Ratio in Endometriosis

目的探讨中性粒细胞/淋巴细胞比值(NLR)在子宫内膜异位症(EM)中的临床意义。方法 EM患者59例,卵巢良性肿瘤患者61例及健康妇女64例,用自动血液学分析仪检测白细胞及其亚型,计算NLR;用微粒子酶免疫分析法测定血清CA125抗原。结果 NLR、CA125在EM组明显高于良性卵巢肿瘤组及健康组(P<0.01),而后两组间比较差异无统计学意义(P>0.05)。在EM患者中NLR在不同分期组间差异无统计学意义(P>0.05);CA125在早期EM组明显低于中晚期EM患者(P<0.01)。早期EM患者中NLR阳性率为89.7%,明显高于CA125(31.0%);并联指标阳性率为93.1%。中晚期EM患者NLR阳性率为86.7%,CA125为63.3%,并联指标为90.0%。在不同病期EM患者中,CA125在不同病期EM组间的阳性率差异有统计学意义(P<0.05)。NLR和并联指标与EM病期无明显的相关性(P>0.05),而CA125与EM分期明显相关(r=0.999,P<0.01)。结论 NLR是一种新的炎症指标,对EM患者的筛查有较好的价值,同时也表明异常炎症反应及免疫抑制是EM的显著特征。

Objective To explore the clinical value of neutrophil-to-lymphocyte ratio（NLR）in endometriosis（EM）.Methods 59 EM patients,61 cases with benign ovarian tumor and 64 healthy controls were enrolled in the study.Leukocytes and its subtypes were detected by automated hematology analyzerand their NLR were calculated.CA125 were determined by microparticle enzyme immunoassay.Results The levels of NLR and CA125 in EM group were obviously higher than those of benign ovarian tumors group and control group（P0.01）,and there was no obvious difference between the latter two groups（P0.05）.There were no obvious differences in NLR in different stages of EM（P0.05）.But the level of CA125 in minimal-to-mild EM group was significantly lower than that of the moderate-to-severe group（P0.01）.The positive rate of NLR in minimal-to-mild EM group was 89.7%,and the figure of CA125 stood at 31.0%,and the positive rate of combined markers（either NLR or CA125 was positive）93.1%.In moderate-to-severe group,the positive rates of NLR,CA125 and combined marker were 86.7%,63.3%,and 90% respectively;the positive rates of NLR and combined markers between different stages EM groups were no significant difference（P0.05）.However,the statistical differences of positive rates of CA125 were quite significant between different stages of EM（P0.051）.No obvious correlation between NLR,combined markers and the EM stages were observed（P0.05）,but there was significant correlation between CA125 and stages of the disease（r=0.999,P0.01）.Conclusion The determination of NLR may be a new indicator of inflammatory,Which has a good value on EM screening,This study indicates that abnormal inflammatory reaction and immunodeficiency are features of patients with EM.