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HLA-G~＊0105N（rs41557518）多态性与新疆哈萨克族食管癌遗传易感性的研究 被引量：1

Relationship between the polymorphism of HLA-G~＊0105N（rs41557518） and the susceptibility of esophageal cancer in Kazakh nationality in Xinjiang
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摘要 目的初步探讨人类白细胞抗原G(human leukocyte antigen G,HLA-G)*0105N基因(rs 41557518)多态性与新疆哈萨克族(哈族)食管癌遗传易感性的关系。方法采用病例-对照研究方法 ,调查新疆地区哈族食管癌患者132例(病例组)和健康对照254例(对照组),应用PCR-RFLP方法检测HLA-G*0105 N(rs 41557518)多态性。结果基因型C/-、C/C-、/-,在病例组中的频率分别为8.33%、91.67%、0%,在对照组中的频率分别为11.95%、88.05%、0%。两组间基因型频率分布差异无统计学意义(χ2=1.19,P>0.05)。结论 HLA-G*0105 N多态性与新疆哈族食管癌遗传易感性无相关性。 Objective To determine the association between the human leukocyte antigen G（HLA-G）＊0105 N（rs 41557518） polymorphism and the susceptibility of esophageal cancer in Kazakh in Xinjiang.Methods A case control study was conducted.The polymorphism of HLA-G＊0105 N（rs 41557518） was analyzed by PCR-RFLP methods in 132 cases of esophageal cancer and 254 healthy controls of Kazakh nationality in Xinjiang area.Results（1） The frequencies of HLA-G＊0105 N genotypes,C/-,C/C,-/-were 8.33%,91.67%,0% and 11.95%,88.05%,0% in Kazakh＇s cases and controls respectively.There was no significant difference in the frequencies of HLA-G＊0105 N genotypes between cases and controls（χ2=1.19,P0.05）.Conclusion HLA-G＊0105 N polymorphism is not associated with the susceptibility of esophageal cancer in Kazakh nationality in Xinjiang.
作者 高秀静 陈艳 阿合力.马斯肉拉 王洪疆 邓彦超 马彦清 张慧霞 王莹
机构地区 新疆医科大学公共卫生学院 新疆食管癌研究所 新疆医科大学附属肿瘤医院 新疆医科大学第一附属医院 新疆伊犁州友谊医院 新疆医科大学
出处 《新疆医科大学学报》 CAS 2010年第4期343-345,349,共4页 Journal of Xinjiang Medical University
基金 国家自然科学基金项目(30460118)
关键词 HLA-G 食管癌 遗传易感性 基因多态性 哈萨克族 human leukocyte antigen G esophageal carcinoma susceptibility genetic polymorphism Kazakh nationality
分类号 R730.2 [医药卫生—肿瘤] R735.1 [医药卫生—肿瘤]
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参考文献14

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新疆医科大学学报
2010年 第4期

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