BRCA1、EGFR在乳腺基底细胞样癌中的表达及临床意义

Expression and clinical pathological of BRCA1,EGFR in basal-like breast carcinoma

目的探讨乳腺癌易感基因(Breast Cancer Susceptibility Gene 1,BRCA1)、表皮生长因子受体(Epider-mal Growth Factor Receptor,EGFR)在乳腺基底细胞样癌中的表达及临床意义。方法应用免疫组织化学PV-9000法,检测83例乳腺基底细胞样癌(basal-like breast carcinoma,BLBC)中BRCA1,EGFR的表达。结果 (1)BLBC中BRCA1阳性表达率为57.83%(48/83),BRCA1表达在不同年龄、不同腋窝淋巴结转移情况、不同临床分期,不同组织学分级各组间差异有统计学意义(P<0.05)。(2)BLBC中EGFR阳性表达率为87.95%(73/83),EGFR的表达在不同临床分期、不同淋巴结转移情况各组间差异有统计学意义(P<0.05)。(3)BRCA1和EGFR表达相互之间未发现相关性(P=0.051)。结论 BRCA1和EGFR在BLBC组织内参与癌组织的转移,可作为评估BLBC预后的有用指标。

Objective To study the expression and clinical pathological significance of breast caner susceptibility gene（BRCA1）,epidermal gronth factor receptor（EGFR） in basal-like breast carcinoma.Methods PV-9000 immunohisto-chemistry technique was applied to detect the expression of BRCA1,EGFR in 83 basal-like breast carcinoma（BLBC） cases.Results（1） The positive rate of BRCA1 was 57.83%（48/83） in BLBC.The expression of BRCA1was associated with age,metastasis of axillary lymph nodes,clinical stage and histopathological grading（P0.05）.（2） The positive rate of EGFR in BLBC was 87.95%（73/83）.The expression of EGFR was associated with metastasis of axillary lymph nodes and clinical stage（P0.05）.（3）There was no significant correlation between the expression of BRCA1and EGFR（P=0.051）.Conclusion BRCA1 and EGFR may play important roles in basal-like breast carcinoma metastasis,which will be considered as valuable biological indexes for assessmenting the prognosis of BLBC.