桑白皮的化学成分研究

Studies on the Chemical Constituents of the Root Bark of Morus alba L.

采用硅胶和凝胶柱层析方法对桑白皮(Cortex Mori)的化学成分进行分离纯化,并根据理化性质和光谱数据分析鉴定得到11个化合物,分别是:羟基白藜芦醇(Hydroxyresveratrol,1),桑叶苷A(mulberroside A,2),熊果酸(ursolic acid,3),3-乙酰基-α-香树酯醇(3-acetyl-α-amyranol,4),熊果烷(ursane,5),β-谷甾醇(β-sitosterol,6),胡萝卜苷(daucosterol,7),十六碳烷酸(palmitic acid,8),十八碳烷酸(stearic acid,9),二十六烷酸-α-单甘油酯(α-glycerol monohexacosanoate,10),二十八烷酸-α-单甘油酯(α-glycerol monooctacosanoate,11)。其中化合物5、8～11均为首次从桑白皮中获得。

The constituents of the root bark of Morus alba L. were isolated by column chromatograpgy on silica gel and Sephadex LH-20, their structures were elucidated by physicochemical properties and spectral analysis. Eleven compounds were iaolated and identified as hydroxyresveratrol （ 1 ）, mulberroside a （2）, ursolic acid （3） ,3-acetyl-α-amyranol （4）, ursane （5） , β-sitosterol （ 6 ） , daucosterol （ 7 ） , palmitic acid （ 8 ） , stearic acid （ 9 ） , α-glycerol monohexacosanoate （10） ,α-glycerol monooctacosanoate （11）. Compounds 5,8-11 were obtained from Cortex Mori for first time.