摘要
目的:评价牙周基础治疗对慢性牙周炎临床疗效及龈下牙周致病菌的影响。方法:纳入慢性牙周炎患者120例,在牙周基础治疗前和治疗后1个月时检查牙周探诊深度(probing depth,PD)、附着丧失(attachment loss,AL)、菌斑指数(plaque index,PLI)和牙龈指数(gingival index,GI)。采用实时荧光定量聚合酶链反应法(real-timePCR)检测基础治疗前和治疗后6周时龈下菌斑中牙龈卟啉单胞菌(P.g)和伴放线放线杆菌(A.a)比例的变化。采用SAS6.12软件包对所得数据进行t检验。结果:各项指数在治疗前、后比较差异有统计学意义(P<0.05)。治疗后P.g占总菌的比例与基线相比有显著性差异(P<0.05),治疗后A.a占总菌的比例与基线相比,无显著差异(P>0.05)。结论:基础治疗可以有效治疗慢性牙周炎,并能降低致病菌P.g的比例。
PURPOSE: To evaluate the effect of periodontal initial therapy on clinical parameters and subgingival periodontal pathogen in patients with chronic periodontitis. METHODS: One hundred and twenty patients with chronic periodontitis were included. Probing depth (PD), attachment loss (AL), plaque index (PLI) and gingival index (GI) were evaluated at baseline and after-initial therapy. P.g and A.a in subgingival plaque were investigated by real-time PCR. Data was statistically analyzed by SAS6.12 software for Student’s t test. RESULTS: The PD, AL, PLI and GI were significantly decreased after periodontal initial therapy (P0.01), and meanwhile the ratio of P.g versus total bacteria was significantly decreased after-initial therapy (P0.05). However, the change of ratio of A.a versus total bacteria was not significant (P0.05). CONCLUSION: Periodontal initial therapy could effectively control the inflammation of chronic periodontitis, and decrease the ratio of P.g in subgingival plaque. Supported by National "11th Five-year" Science and Technology Supporting Project(Grant No.2007BAI18B02) and Shen-Kang Research Fund of Shanghai Municipality(Grant No.SHDC12007210).
出处
《上海口腔医学》
CAS
CSCD
2010年第3期225-227,共3页
Shanghai Journal of Stomatology
基金
“十一五”国家科技支撑计划(2007BAI18B02)
上海市申康基金(SHDC12007210)
关键词
慢性牙周炎
临床指标
牙龈卟啉单胞菌
伴放线放线杆菌
Chronic periodontitis
Clinical parameter
Porphyromonas gingivalis
Actinobacillus actinomycetemcomitans