基础治疗对慢性牙周炎临床疗效和龈下牙周致病菌的影响

The effect of periodontal initial therapy on chronic periodontitis and subgingival periodontal pathogen

目的:评价牙周基础治疗对慢性牙周炎临床疗效及龈下牙周致病菌的影响。方法:纳入慢性牙周炎患者120例,在牙周基础治疗前和治疗后1个月时检查牙周探诊深度(probing depth,PD)、附着丧失(attachment loss,AL)、菌斑指数(plaque index,PLI)和牙龈指数(gingival index,GI)。采用实时荧光定量聚合酶链反应法(real-timePCR)检测基础治疗前和治疗后6周时龈下菌斑中牙龈卟啉单胞菌(P.g)和伴放线放线杆菌(A.a)比例的变化。采用SAS6.12软件包对所得数据进行t检验。结果:各项指数在治疗前、后比较差异有统计学意义(P<0.05)。治疗后P.g占总菌的比例与基线相比有显著性差异(P<0.05),治疗后A.a占总菌的比例与基线相比,无显著差异(P>0.05)。结论:基础治疗可以有效治疗慢性牙周炎,并能降低致病菌P.g的比例。

PURPOSE： To evaluate the effect of periodontal initial therapy on clinical parameters and subgingival periodontal pathogen in patients with chronic periodontitis. METHODS： One hundred and twenty patients with chronic periodontitis were included. Probing depth （PD）, attachment loss （AL）, plaque index （PLI） and gingival index （GI） were evaluated at baseline and after-initial therapy. P.g and A.a in subgingival plaque were investigated by real-time PCR. Data was statistically analyzed by SAS6.12 software for Student’s t test. RESULTS： The PD, AL, PLI and GI were significantly decreased after periodontal initial therapy （P0.01）, and meanwhile the ratio of P.g versus total bacteria was significantly decreased after-initial therapy （P0.05）. However, the change of ratio of A.a versus total bacteria was not significant （P0.05）. CONCLUSION： Periodontal initial therapy could effectively control the inflammation of chronic periodontitis, and decrease the ratio of P.g in subgingival plaque. Supported by National ＂11th Five-year＂ Science and Technology Supporting Project（Grant No.2007BAI18B02） and Shen-Kang Research Fund of Shanghai Municipality（Grant No.SHDC12007210）.