摘要
光照能明显改变正常人和动物瞳孔的大小,而精神疾病及药物滥用则影响人和动物瞳孔对光的反应性。因此,瞳孔对光反应异常可以用作检测精神疾病和药物滥用的指标。有关药物滥用是如何影响瞳孔对光的反应性的研究还很少。为定量地测量成瘾性药物对瞳孔光反应变化的影响,该文采用猕猴为实验对象,通过在黑暗环境中测量猕猴在吗啡给予前和吗啡给予后的不同时间段,其瞳孔直径大小以及其对光反应能力的变化情况,来系统研究吗啡是如何影响这种非自主性反射系统的。研究发现,吗啡给予降低了猕猴在黑暗环境中的扩瞳反应,并且降低了瞳孔对光反应的收缩率。该文为将瞳孔对光反应特征用作鉴定吸毒者的检测手段提供了实验依据。
The pupil size of both human and other animals can be affected by light. Many kinds of psychiatrical and psychological disorders, such as drug abuse, associate with abnormal properties of pupillary light reflex. Thus, the properties of pupillary light reflex could serve as an indicator for drug abuse detection. However, the effect of drug abuse on pupillary light reflex is till unclear. To assess the effects of addictive drugs on pupillary light reflex quantificationally, in the present study, we examined the effects of morphine on pupil diameter and pupillary light reflex in rhesus monkeys. By measuring the pupil diameter at different timing points before and after the administration of morphine, we found that morphine administration reduced the diameter of pupil and decreased the constriction rate. Our present results provide an experimental support for applying the properties of pupillary light reflex as a reference in addicts’ detection.
基金
国家高技术研究发展计划("863"项目)(O7013810
2006AA02A116)
国家自然科学基金(NSFC30530270
30670669
30870825
30770700)
关键词
猕猴
吗啡
瞳孔直径
瞳孔对光反应
Monkey
Morphine
Pupil diameter
Pupillary light reflex
