射频数据处理技术定量评价健康人颈总动脉内-中膜厚度和血管弹性的研究

Quantitative evaluation of common carotid arterial intima-media thickness and elasticity in healthy adults by ultrasound radio-frequency data technology

目的 应用高频超声射频数据处理（ultrasound radio-frequency data,RF-data）技术定量检测健康人颈总动脉内-中膜厚度（intima-media thickness,IMT）和血管弹性,确定相关参数的正常值范围.方法 对160例健康人根据年龄分为4组（30～39岁,40～49岁,50～59岁,60～69岁）,每组40例,男性20例,女性20例;RF-data技术获取健康者双侧颈总动脉IMT、颈总动脉扩张性（CD）、单点脉搏波传播速度（PWVβ）、僵硬度（β）,并分析各参数之间及与年龄、性别的关系.结果 ①IMT、PWVβ和β与年龄呈显著正相关,CD与年龄负相关;IMT、CD、PWVβ和β与性别相关性不显著;②IMT与PWVβ、β呈显著正相关,而与CD相关性不显著;PWVβ与β显著正相关,而与CD显著负相关;③随着年龄的增加,IMT亦随之增高（P＜0.05）.在30～39岁、40～49岁组中,随年龄增加PWVβ增高,而CD减低明显（P＜0.05）;50～59岁组PWVβ和β增高显著（P＜0.05）;在60～69岁组,随年龄增加CD、PWVβ、β差异无统计学意义.④CD、PWVβ和β的正常值在60～69岁组分别为（329.39±102.06）μm、（7.22±1.91）m/s和10.04±4.91,而在＜60岁者随年龄不同而异.结论 RF-data技术能够准确检测颈总动脉IMT和血管弹性,根据年龄确立正常值范围,为临床定量评估血管性能提供新的手段.

Objective To evaluate common carotid arterial intima-media thickness （IMT） and elasticity using ultrasound radio-frequency data （RF-data） technology, the normal values of the related parameters were determined in healthy adults for their potential clinical applications.Methods One hundred and sixty healthy adults were included and divided into 4 age groups with 20 males and 20 females in each group.The quantitative parameters of common carotid arterial IMT, common carotid arterial distensibility （CD）,local pulse wave velocity（PWVβ） and stiffness（β） were calculated automatically.The correlations that the IMT, PWVβ and β were correlated positively with aging and CD was correlated negatively with between IMT and PWVβ or β, while no correlation between IMT and CD.The positive correlation was found correlation between IMT and age （ P〈0.05） ;In 30～39 and 40～49 years old groups,PWVβ increased and CD decreased with aging;In 50～59 years old group,PWVβ and β increased with aging;But in 60～69 years these parameters changed with aging in subjects〈60 years old.Conclusions RF-data technology could quantitativly evaluate common carotid arterial IMT and elasticity, the normal values of the related parameters were determined with aging,it may be a promising modality to assess the arterial condition.