藏族CYP17与CYP19基因多态性与身高的相关关系

Correlation of CYP17 and CYP19 gene polymorphisms with height in Tibetan

目的：探讨西藏藏族人群CYP17与CYP19基因多态性与人体身高发育的关系。方法：收集长期居住西藏且体检健康的藏族人血液标本200例（男108例，女92例），并同时测量其身高，提取DNA，设计引物，通过RFLP-PCR法对CYP17基因多态性进行检测；对CYP19基因经PCR扩增，电泳并回收后进行直接测序。结果：CYP17基因MspAII酶切位点基因多态性与藏族男性身高发育有关；与女性身高发育无明显相关性。CYPl9基因多态性与男、女身高均无相关。结论：CYP17基因可能是影响藏族男性身高个体差异的基因之一，而CYP19基因对藏族人群身高影响不明显。

Objective： To explore the relationship of the CYP17 and CYP19 gene polymorphisms with height in Tibe-tans. Methods： We collected blood sample from 200 healthy Tibetans （108 men and 92 women） , all of whom were long-term residents of Tibet, and measured their height and extracted DNA; the polymorphism of CYP17 gene was detected by RFLP PCR; CYP19 gene was detected by direct sequencing after PCR amplification. Results： CYP17 gene MspAII enzyme gene polymorphism was associated with male height; there was no significant correlation with female height. CYP19 gene polymorphism had no correlation with neither male nor female height. Conclusion： CYP17 gene may be one of the genes which affect the height of Tibetan men, and CYP19 gene had no significant effect on Tibetan height.