单侧感音神经性耳聋患者听觉皮层的BOLD-fMRI研究

BOLD-fMRI of auditory cortical responses in patients with unilateral sensorineural hearing loss

目的利用血氧水平依赖功能磁共振(BOLD-fMRI)成像技术,探讨单侧感音神经性耳聋患者听觉皮层优势半球的变化及可能存在的功能重组。方法选取重度单侧长期感音神经性耳聋患者21例(13例左耳聋,8例右耳聋),采用Sparse设计进行正弦调幅音(AM)任务下的fMRI数据采集,实验刺激为500Hz的载波频率,8Hz的AM,耳聋患者健耳呈现。采用1.5T超导型MRI成像系统,采集脑部的BOLD-fMRI数据后,通过SPM2软件对数据进行统计学分析,得到脑功能活动的图像。结果单侧长期感音神经性耳聋患者健耳给声,双侧听觉皮层均有激活,但仍为对侧半球优势。结论听觉中枢具有可塑性,单侧感音神经性耳聋患者听觉皮层存在着结构重组。

Objective Auditory cortical response to amplitude modulation（AM）was evaluated using BOLD-fMRI in the patients with unilateral sensorineural hearing loss（USNHL）.Methods A total of 21 patients with USNHL（left in 13 ears,right in 8 ears）was examined with BOLD-fMRI in response to AM tones of 500Hz with the modulation frequency at 8Hz.An event-related design was combined with a sparse clustered volume acquisitioning paradigm in data collection in the attempt to reduce the influence of acoustic scanner noise.With 1.5T MRI imaging system,BOLD-fMRI data of brain cortex were collected and analyzed using SPM2 softwere to produce a dynamic images of the brain.Results When the auditory signals were given to unilateral ear of USNHL patients,bilateral auditory cortexes were activated with a clear contralateral predominance.Conclusion The results indicate that the plasticity and strueturdlly remoduling of auditory cortex of patients with USNHL exist.