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治疗骨质疏松症靶向药物研究进展 被引量：1

Advances in research of targeted drugs for osteoporosis
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摘要 骨质疏松症(Osteoporosis,OP)是世界性高发生率的、易于引发骨折为特征的代谢性疾病。其治疗药物主要有促骨合成药和抑制骨吸收药。随着对其发病机制研究的不断深入,多肽、激素、细胞因子等靶向药物成为研究的热点。本文阐述的促骨合成药有:PTH、钙敏感受体负向调节剂calcilytics、雷尼酸锶、PYK2抑制剂;抑制骨吸收药有OPG、Denosumab;抑制骨基质降解的组织蛋白K等新型药物。它们有的已经上市,有的处于临床研究中。 Osteoporosis is a worldwide metabolic disease with a high prevalence. Agents for the treatment of osteoporosis are classified as either antiresorptive or anabolic. With the deep research on its pathogenesis, various novel agents are under development. OPG, denosumab, Cathepsin K inhibitor, PTH and PTHrP, calcium-sensing receptor, strontium ranelate and PYK2 inhibitor are summarized in this review.
作者 刘璐 闫玉仙 张西正
机构地区 军事医学科学院卫生装备研究所 武警医学院化学教研室
出处 《中国骨质疏松杂志》 CAS CSCD 2010年第6期450-453,449,共5页 Chinese Journal of Osteoporosis
基金 国家自然科学重点基金(No10832012)
关键词 骨质疏松 信号转导 钙敏感受体负向调节剂 PYK2抑制剂 组织蛋白酶K抑制剂 Osteoporosis Signal transduction Calcium-sensing receptor PYK2 inhibitor Cathepsin K inhibitor
分类号 R681 [医药卫生—骨科学]
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参考文献35

  • 1Iacovino JR. Mortality outcomes after osleoporotic fractures in men and women. J Insur Med,2001,33 :316-320.
  • 2Suda T,Takahashi N,Udagama N,et al. Modulation of ostroclast difterentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev, 1999, 20 :345 -357.
  • 3Kostenuik PJ, Shalhoub V. Osteoprotegerin: a physiological and pharmacological inhibitor of bone resorption. Curr Pharm Des, 2001,7:613-635.
  • 4Rodan GA, Martin TJ. Therapeutic approaches to bone diseases. Science,2000,289 : 1508-1514.
  • 5Anne Fouque-Aubert, Roland Chapurlat. Influence of RANKL inhibition on immune system in the treatment of bone diseases. Joint Bone Spine,2008, 75: 5-10.
  • 6Body JJ, Greipp P. Coleman RE, et al. A phase 1 study of AMGN..O007, a recombinant osteoprotegerin construct, in patients with muhiple myeloma or breast carcinoma related bone metastases. Cancer, 2003,97 : 887-892.
  • 7Bekker PJ, Holloway DL, Rasmussen AS, et al. A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J Bone Miner Res, 2005,20:2275-2282.
  • 8Rouxa C, Bologneseb MA, Bianchic G, et al. Relationship between baseline bone turnover marker levels and percent change in BMD at month 12 in postmenopausal women transitioned to denosumab or continuing on long-term alendronate therapy. J Bone, 2009,44: 476.
  • 9Ishikawa T, Kamiyama M, Tani Ishii N, et al. Inhibition of osteoclast differentiation and bone resorption by cathepsin K antisense oligonucleotides. Mol Carcinog,2001,32:84-91.
  • 10Adami S. Effect of one year treatment with the cathepsin-K inhibitor, balicatib, on bone mineral density in postmenopausal women with osteopenia/osteoporosis[ abstract #1085 ]. Presented at the 28^th Annual Meeting of the American Society for Bone and Mineral Research: 2006 September 15-19 ;Philadelphia, PA.

同被引文献12

  • 1David H. Kim,Alexander R. Vaccaro.Osteoporotic compression fractures of the spine; current options and considerations for treatment[J].The Spine Journal.2006(5)
  • 2Douglas Wardlaw,Steven R Cummings,Jan Van Meirhaeghe,Leonard Bastian,John B Tillman,Jonas Ranstam,Richard Eastell,Peter Shabe,Karen Talmadge,Steven Boonen.Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE): a randomised controlled trial[J].The Lancet.2009(9668)
  • 3I. Fogelman,J. N. Fordham,W. D. Fraser,T. D. Spector,C. Christiansen,S. A. Morris,J. Fox.Parathyroid Hormone(1–84) Treatment of Postmenopausal Women with Low Bone Mass Receiving Hormone Replacement Therapy[J].Calcified Tissue International.2008(2)
  • 4Steven R. Garfin,Hansen A. Yuan,Mark A. Reiley.New Technologies in Spine: Kyphoplasty and Vertebroplasty for the Treatment of Painful Osteoporotic Compression Fractures[J].Spine.2001(14)
  • 5D. Haguenauer,V. Welch,B. Shea,P. Tugwell,J. D. Adachi,G. Wells.Fluoride for the Treatment of Postmenopausal Osteoporotic Fractures: A Meta-Analysis[J].Osteoporosis International.2000(9)
  • 6陈亮,杨惠林,唐天驷.后凸成形术治疗多椎体骨质疏松性压缩骨折的疗效分析[J].中华骨科杂志,2009,29(4):310-314. 被引量：41
  • 7陈东阳,王惠冰,顾新,蒋青,袁涛,徐志宏.低分子肝素钙致全髋关节置换术患者大量渗血[J].药物不良反应杂志,2009,11(2):135-136. 被引量：14
  • 8徐宝山,胡永成,闫广辉,夏群,黄震源,吉宁,张继东,苗军,宁尚龙,谭清实,周静.经皮椎体成形术和后凸成形术的相关问题探讨[J].中华骨科杂志,2009,29(5):430-435. 被引量：60
  • 9王谦,刘光军,许硕贵.各类抗骨质疏松药物的临床研究进展[J].实用医药杂志,2010,27(4):368-371. 被引量：23
  • 10郭成龙,张晓刚,宋敏,杨国栋.骨质疏松症药物治疗的研究进展[J].中国中医骨伤科杂志,2010,18(6):65-68. 被引量：10

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中国骨质疏松杂志
2010年 第6期

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