载药人工骨预防人工关节感染的研究进展

Research on prevention of artificial joint infection by drug-loaded artificial bone

骨质疏松患者人工关节置换后,感染是手术后严重的并发症之一,它延长治疗进程,增加医疗开支,降低治疗效果,常常导致手术彻底失败,或造成病人残废,严重者甚至死亡。载药人工骨作为一种有效的辅助治疗措施,已被广泛应用于慢性骨髓炎等临床治疗,并在人工关节术后感染的防治上发挥越来越重要的作用。该文就人工关节感染的特性,载药人工骨的分类及其作用、潜在缺点,以及在预防人工关节感染中的病例选择做一综述。

One of the complications after total joint arthroplasty is the artificial joint infection. It extends the treatment process, increases the medical treatment expenditures and weakens the treatment effect. Sometimes the artificial joint infection would induce the failure of the arthroplasty or make the patients disable or even seriously dead. To solve this problem, the drug-loaded artificial bone as an effective auxiliary method was introduced and applied to the clinical treatment of the chronic osteomyelitis. And this method plays an increasingly important role in the prevention and treatment of postoperative infection after the arthroplasty. This paper mainly makes a brief summary of the characteristics of artificial joint infection, the classification and effect of the drug-loaded artificial bone, and the clinical infect cases in the prevention of artificial joint infection.