结外型口腔恶性淋巴瘤临床病理分析

Clinicopathology of Extra-nodal Lymphoma in Oral and Maxillofacial Region

目的:研究结外型口腔恶性淋巴瘤的发病情况和临床病理特点。方法:对青岛大学医学院附属医院口腔颌面外科1988-07—2008-12收治的24例结外型口腔恶性淋巴瘤患者进行回顾性临床病理分析,研究其发病年龄、发病部位、病理分型及临床表现。结果:结外型口腔恶性淋巴瘤发病率低,分布于各个年龄段,男性发病多于女性,可发生于舌根、腭、颊、唇、牙龈等部位,临床表现多样,多为非霍奇金淋巴瘤,以B细胞恶性淋巴瘤多见。结论:结外型口腔恶性淋巴瘤临床表现多样,应注意鉴别诊断。肿块切取活检,辅以全身系统性检查,是诊断结外型口腔恶性淋巴瘤的有效手段。

Objective： To study the prevalence situation, clinicopathologic features of extra-nodal lymphoma in oral and maxillofacial region. Methods： The elinicopathologic features of 24 cases from July 1988 to December 2008 were investigated, including onset ages, site, classification and clinical manifestations. Results： The incidence rate of extra- nodal lymphoma in oral and maxillofacial region was lower. It occurred in every age group, with males more than females. It located in tongue base, palate, bucea, lip, gum. Clinical manifestations of oral lymphoma were varied, including tumor, inflammation, ulcer and necrosis. The pathological diagnosis were mainly non-Hodgkin＇ s lymphoma, most of them were B cell malignant lymphoma. Conclusion： Clinical manifestations of extra-nodal lymphoma in oral and maxillofaeial regions were diversed. Differential diagnosis should be careful. Mass biopsy and general physical examination would be ,helpful to the diagnosis.