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Y-box结合蛋白-1在胃癌组织中的表达及意义 被引量：3

Expression and significance of Y-box-binding protein-1 in gastric carcinoma
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摘要 目的研究Y-box结合蛋白-1(YB-1)在胃癌的不同发展阶段中的表达及其意义。方法采用免疫组织化学和原位杂交方法检测正常胃组织、肠化生组织、早期胃癌和进展期胃癌组织中YB-1蛋白和mRNA的表达变化。结果在正常胃组织中YB-1蛋白和mRNA无表达;在肠化生组织中可见YB-1阳性染色于胃黏膜上皮细胞中,但表达较弱;在早期胃癌中YB-1表达于全层胃黏膜上皮细胞中,染色较肠化生组织重,而在进展期胃癌中其表达较在早期胃癌中下降。结论 YB-1的升高可能在胃癌的早期发生和发展中起作用。 Objective To investigate the expression and significance of Y-box-binding protein-1（YB-1） in patients with gastric carcinoma of different stages. Methods Expressions of YB-1 protein and mRNA in specimens of normal tissues,intestinal metaplasia,early gastric cancer and advanced gastric cancer were detected by immunohistochemistry and in situ hybridization. Results There was no positive staining of YB-1 protein and mRNA in normal gastric tissues. However,YB-1 was expressed in epithelial cells of gastric mucosa in intestinal metaplasia. YB-1 was expressed in all layers of gastric mucosa of epithelial cells in the early stage of gastric cancer,and its expression was weaker in advanced gastric cancer than in early gastric cancer. Conclusion Elevated YB-1 may be related to the early pathogenesis and development of gastric carcinoma.
作者 王国荣 车向明 吴开杰 邱健 潘承恩 王晓强 何文宪
机构地区 西安交通大学医学院第一附属医院普外科 陕西省人民医院普外科
出处 《西安交通大学学报（医学版）》 CAS CSCD 北大核心 2010年第4期487-489,共3页 Journal of Xi’an Jiaotong University（Medical Sciences）
基金 陕西省科学技术研究发展计划项目[No .005K09-G3(3)]~~
关键词 胃癌 Y-box结合蛋白-1 免疫组织化学 原位杂交 gastric carcinoma YB-1 immunohistochemistry in situ hybridization
分类号 R758.63 [医药卫生—皮肤病学与性病学]
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参考文献10

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同被引文献46

  • 1乔岩瑞.冷应激对猪生产性能的影响[J].养猪,2004(6):25-27. 被引量：10
  • 2周传臣,张玉芝,高健.东北民猪de优良特性[J].养殖技术顾问,2005(2):10-10. 被引量：13
  • 3张玮玮,黄惠芳,李庆伟,马飞.Y-box结合蛋白功能及对肿瘤发生的影响[J].遗传,2006,28(9):1153-1160. 被引量：4
  • 4DIDIER D K,SCHIFFENBAUER J,WOULFE S L,et al. Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box [J]. Proc Natl Acad Sci USA, 1988, 85(19): 7322-7326.
  • 5EVDOKIMOVA V,RUZANOV P,IMATAKA H,et al. The major mRNAassociated protein YB1 is a potent 5′capdependent mRNA stabilizer [J]. Embo J,2001,20: 5491-5502.
  • 6KOHNO K,IZUMI H,UCHIUMI T,et al. The pleiotropic functions of the Y-boxbinding protein, YB1 [J]. Bioessays,2003,25(7): 691-698.
  • 7KHANDELWAL P,PADALA M K,COX J,et al. The Nterminal domain of ybox binding protein1 induces cell cycle arrest in g2/m phase by binding to cyclin d1 [J].Int J Cell Biol,2009,Article ID 243532, 11 pages, doi:10.1155/2009/243532.
  • 8CATHELIJNE P A M K,CHRISTIAN A E M S,EDWIN L,et al. The solution structure and DNAbinding properties of the coldshock Domain of the human Ybox protein YB1 [J].J Mol Biol,2002,316: 317-326.
  • 9杨光,李晓璐,盛清,等.家蚕Y-Box 蛋白的克隆表达以及功能分析[J].中国科技论文在线(http://www.paper.edu.cn):1-13.
  • 10CHIBI M,MEYER M,SKEPU A,et al. RBBP6 interacts with multifunctional protein YB1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB1 [J].J Mol Biol,2008,384(4): 908-916.

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西安交通大学学报（医学版）
2010年 第4期

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