IGF-Ⅰ IGF-Ⅱ在胃癌中的表达及临床意义

Expression and Clinical Significance of Insulin-like Growth Factor-Ⅰand Insulin-like Growth Factor-Ⅱ in Gastric Cancer

目的:探讨IGF-Ⅰ、IGF-Ⅱ在胃癌中的表达与胃癌的发生、发展、分期、浸润和转移等生物学行为的关系。方法:应用免疫组化S-P法检测40例胃癌(GC)中IGF-Ⅰ、IGF-Ⅱ的表达,并结合临床资料进行研究,以胃镜活检经病理证实的20例正常胃组织作为对照组。采用X2检验。结果:胃癌、癌旁组织IGF-Ⅰ、IGF-Ⅱ的表达率较正常胃组织明显增高(P<0.01),且IGF-Ⅰ、IGF-Ⅱ的表达与胃癌的分化程度、浸润深度、肿瘤大小、淋巴结转移、及TNM分期密切相关(P<0.05),而与性别及年龄无关。结论:IGF-Ⅰ、IGF-Ⅱ在胃癌中的过表达与胃癌发生发展及浸润转移有关,是胃癌发生过程中一个重要事件,对胃癌的发生发展有促进作用。

Objective：To study the relationship between the expression of insulin-like growth factor-Ⅰ,Ⅱ and the biological behaviors of gastric cancer （GC）,such as occurrence,development,histological stage,infiltration and metastasis.Method：The expression of IGF-Ⅰand Ⅱwas detected by S-P immunohisto-chemistry method in 40 cases of GC,the control group included 20 cases of normal gastric tissues which were certified by biopsy.The statistic method was Chi-square test.Result：The rates of the expression of IGF-I and Ⅱ in GC group and paracancer group were much higher than that in control group （P0.01）.The expression of IGF-Ⅰand Ⅱ was closely correlated to tumor differentiation,depth of infiltration,tumor size,lymph node metastasis and TNM stage （P0.05）,while no correlation with gender and age.Conclusion：The excessive expression of IGF-Ⅰand IGF-Ⅱin GC is correlated with the carcinogenesis,infiltration and metastasis.They may play an important role in the occurrence of GC and may accelerate the development of GC.