基于点击化学的铕配合物纳米颗粒对Cu(Ⅰ)离子的检测(英文)

Cu(Ⅰ) Ion Detection with Europium(Ⅲ) Chelate Nanoparticles Based on Click Chemistry

制备了Eu(Ⅲ)配合物纳米颗粒并对其进行表面修饰以用于Cu(I)离子的检测。所采用的探测机制是源于Cu(I)离子催化的末端炔基和叠氮基团之间的1,3极性环加成。通过该反应,在Eu3+配合物纳米颗粒(给体)和一种荧光染料分子(受体)之间建立了共振能量传递关系。因为点击反应的速度正比于Cu(I)离子的浓度,因此通过监测染料分子荧光强度的变化即可检测出Cu(I)离子的浓度。基于共振能量传递机制和点击反应的敏感性,浓度为微摩尔量级的Cu(I)离子可以被探测到。

Europium（Ⅲ） chelate nanoparticles（NPs） were prepared and surface functionalized to detect Cu（Ⅰ） ions.The detection mechanism is based upon 1,3 dipolar cycloaddition of alkynyl groups to azido groups being able to be catalyzed by Cu（Ⅰ）,through which a fluorescent resonance energy transfer（FRET） system is constructed between NP and an acceptor fluorescent dye.By monitoring the fluorescence of the acceptor dye,the concentration of Cu（Ⅰ） ions was reported since the speed of click reaction is proportional to its concentration.Owing to the smart detecting scheme,Cu（Ⅰ） ions（in micromolar concentrations） can be detected.