基于香豆酰肼的高选择性的铜离子荧光探针

Highly Sensitive Fluorescent Coumarin-based Probes for Selective Detection of Copper Ion

设计合成了含有香豆酰肼官能团的铜离子荧光探针,N,N-二乙基氨基香豆素-3-酰肼吡啶醛(XB),该探针在水溶液中[V(CH3CN):V(H2O)=1:1]对铜离子识别和检测具有较高的灵敏度和选择性。碱金属和碱土金属离子K+、Na+、Mg2+、Ca2+以及过渡金属离子Cr3+、Mn2+、Fe3+、Co2+、Ni2+、Zn2+、Cd2+、Hg2+和Ag+等对Cu2+离子的识别无显著影响。光谱滴定和ESI-MS谱表明Cu2+离子与XB以1:2的化学计量比形成配合物。

By combining 7-diethylamino-2-oxo-2H-chromene-3-carbohydrazide with 2-pyridylaldehyde into one molecule,fluorescent probe XB [7-（diethylamino）-2-oxo-N＇-（pyridin-2-ylmethylene）-2H-chromene-3-carbohy-drazide]was synthesized for detection of Cu2 ＋ in aqueous solution V（CH3CN）：V（H2O） = 1：1）.The probe is highly selective for Cu2 ＋ over biologically relevant alkali metals,alkaline earth metals and the first row transition metals such as Cr3 ＋,Mn2 ＋,Fe3 ＋,Co2 ＋,Ni2 ＋,Zn2 ＋,Cd2 ＋ and Hg2 ＋.Spectrophotometric titration and ESI-MS spectra indicate the formation of a 1：2 complex of Cu2 ＋ with XB.