摘要
肽核酸（ＰｅｐｔｉｄｅＮｕｃｌｅｉｃＡｃｉｄｓ，ＰＮＡｓ），是一类用蛋白质骨架代替核酸中的磷酸核糖骨架而形成的新型分子，它不仅保留了与互补的ＤＮＡ或ＲＮＡ配对结合的特性，而且其特异性和亲和性都比相应的寡核苷酸高。同时又能抵抗所有核酸酶和蛋白酶的降解，在分子生物学和医药领域有广泛的应用前景。本文就ＰＮＡ的结构。
出处
《微生物学免疫学进展》
1999年第1期86-90,共5页
Progress In Microbiology and Immunology
同被引文献24
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1[1]Nielsen PE,Egholm M,Berg RH,et al.Sequence selective recognition of DNA by strand displacement with a thymine substituted polyamide.Science,1991,254 (5037):1491～1500.
-
2[2]Cherny D,Belotserkovski BP,Frank Kamenetski M D,et al.DNA unwinding upon strand displacement binding of athymine substituted polyamide to double stranded DNA.Proc Natl Acad Sci U S A, 1993, 90 (5):1667～1670.
-
3[3]Kim S K,Nielsen P E,Egholm M,et al.Right handed trip lex formed between Peptide Nucleic Acids PNA-T8 and Poly (dA) shown by linear and circular dichroism spectroscopy.J.Am.Chem.Soc,1993,115:6477～6481.
-
4[4]W eiler J,Gausepoh LH,Hauser N,et al. Hybridisation based DNA screening on peptide nucleic acid (PNA ) oligomer arrays.Nucleic Acids Research,1997,25 (14):2792～2799.
-
5[7]Norton J C,Piatyszek M A,Wright W E,et al.Inhibition of human telomerase activity by PNAs.Nature Biotech,1996,14(5) :615.
-
6[8]Boffa L C,Morris PL,Carpaneto EM,et al. Invasion of the CAG triplet repeats by a complementary peptide nucleic acid inhibits transcription of the androgen receptor and TATA binding protein genes and correlates with refolding of an active nucleosome containing a unique AR gene sequence.BiolChem,1996,271(22) :13228～13233.
-
7[9]Mologni L,Lecout RE,Nielsen P E,et al. Additive antisense effects of different PNAs on the in vitro translation of the PML/ RAR alpha gene.Nucleic Acids Res,1998,26:1934～1938.
-
8[10]Mologni L,Nielsen P E,Gambacorta-Passerini C.In vitro transcription and translational block of the bcl-2 gene operated by peptide nucleic acid.Biochem Biophys Res Commun 1999,264(2):537～543.
-
9[11]Hanvey J C,Peffer N J,Bisi J E,et al.Antisense and antigene properities of peptide nucleic acids.Science,1992,258:1481～1485.
-
10[12]Bonham MA,Brown S,Boyd A L et al.An assessment of the antisense properties of Rnase H2 competent and steric blocking oligomers.Nucleic Acids Res,1995,23:1197～1203.
-
1吴开国,吴彤,磨传真,郭松超,袁秀玲,唐正心.应用沼气池液培养钝顶螺旋藻的初步探讨[J].广西医学院学报,1990,7(2):11-17. 被引量：4
-
2邓艳春,药立波,苏成芝.PH结构域研究进展[J].生命科学,2000,12(3):117-121. 被引量：8
-
3黄京飞,Tom L.Blundell.蛋白质序列和结构的保守性与其功能的关系[J].Zoological Research,1999,20(1):21-25. 被引量：12
-
4王道尊,汤峥嵘,谭玉钧.中华鳖生化组成的分析──Ⅰ.一般营养成分的含量及肌肉脂肪酸的组成[J].水生生物学报,1997,21(4):299-305. 被引量：45
-
5张玉秀,柴团耀.HSP70分子伴侣系统研究进展[J].生物化学与生物物理进展,1999,26(6):554-558. 被引量：18
-
6吴梧桐.蛋白质营养价值研究进展[J].药物生物技术,1996,3(1):46-53. 被引量：3
-
7李师翁,王毅民.几种化学物质对小球藻生长和蛋白含量的效应[J].微生物学通报,1998,25(2):91-92. 被引量：9
-
8李颖,冯建生.真核生物mRNA的帽结构与帽结合蛋白[J].生命科学研究,1999,3(4):286-291. 被引量：3
-
9阎哲.原核细胞表达的重组蛋白质复性研究进展[J].国外医学（预防．诊断．治疗用生物制品分册）,1997,20(1):10-14. 被引量：3
-
10裴冬生,胡书群,赵惠仁.人白细胞介素18在大肠杆菌中的表达、纯化和复性[J].生物化学与生物物理学报,2000,32(4):397-400. 被引量：9
