80例大疱性皮肤病组织病理及直接免疫荧光结果分析

Analysis of Pathology and Direct Immunofluorescence Test on 80 cases of Bullous Dermatosis

目的:探讨组织病理及直接免疫荧光检查对大疱性皮肤病的诊断意义。方法:对80例大疱性皮肤病患者的皮损进行组织病理检查,并采用鼠抗人免疫球蛋白(IgG,IgM,IgA)及补体C3进行直接免疫荧光检查,对结果进行回顾性分析。结果:本组患者自身免疫性大疱性皮肤病占60.00%,以天疱疮和类天疱疮为主,非自身免疫性大疱性皮肤病以大疱性表皮松解症及大疱性多形红斑多见,不同类型的大疱性皮肤病组织病理及免疫荧光具有特征性。结论:组织病理及直接免疫荧光检查对大疱性皮肤病的诊断、鉴别诊断、治疗、预后判断具有重要的意义。

Objective：To investigate the significance of pathology and direct immunofluorescence test on the diagnosis of bullous dermatosis. Methods：The lesion of 80 cases of bullous dermatosis were tested by pathology and direct immunofluorescence technology（DIF） with rabbit anti-hunman Ig（IgG,IgM,IgA）and complement C3.Results：In this group,60.00% of the patients were auto-immune bullous dermatosis,mainly including pemphigus and bullous pemphigoid.Epidermolysis bullosa and bullous erythema multiforme were common in non-auto-immune bullous dermatosis.Different type of bullous dermatosis have different characteristics of pathology and immunofluorescence.Conclusion：Pathology and direct immunofluorescence test were important for diagnosis,differential diagnosis,therapy and prognosis of bullous dermatosis.