摘要
目的:探讨家族性系统红斑狼疮(systemic lupus erythematosus,SLE)患者发病的环境因素。方法:回顾性分析6个家系13例SLE患者的临床/实验室资料和患者发病前的环境因素。结果:患者发病前环境因素有塑料、电子、铝材、美容产品、铝锡合金等。发病前同住者的5个家系内SLE患者出现的临床表现的一致性较未同住者高,抗核抗体谱的一致性也较未同住者高。结论:上述环境物质可能与SLE的发病过程,其中居住环境也可能影响SLE的表型。
Objective：To explore environmental factors in pathogenesis of systemic lupus erythematosus（SLE）. Methods：Clinical features,lab results,and environmental factors before the onset of 13 SLE patients in 6 families were retrospectively reviewed.Results：Plastic and electronic products,aluminum,cosmetic agents,aluminum-tin alloy were found in close contact with familial SLE patients.Similarity of clinical features and autoantibodies among patients from five families who live together were higher than those of patients from one family who did not live together.Conclusion：Environmental factors in plastic and electronic products,aluminum,cosmetic agents,and aluminum-tin alloy could be involved in SLE.Living environment may affect the phenotype of clinical features and serum autoantibodies.
出处
《皮肤性病诊疗学杂志》
2010年第3期193-194,200,共3页
Journal of Diagnosis and Therapy on Dermato-venereology
关键词
系统性红斑狼疮
家族性
环境
Systemic lupus erythematosus
Familial
Environment
