摘要
同型框基因Ｐｉｔｘ２在鸡、小鼠和爪蟾胚胎中不对称地表达在左侧板中胚层和衍生器官（如心脏、肠等）中．转录因子Ｐｉｔｘ２看来是Ｓｈｈ和Ｎｏｄａｌ等信号分子的下游效应子．Ｐｉｔｘ２的错误表达足以产生器官逆位和身体旋转逆向，人类若有Ｐｉｔｘ２表达缺陷就可能导致Ｒｉｅｇｅｒ综合征．Ｐｉｔｘ２看来是脊椎动物介导左右不对称的关键且保守的信号分子．
Pitx2 is asymmetrically expressed in the left lateral plate mesoderm and derived organs such as heart and gut during chick, mouse and Xenopus development . Pitx2 appears to be downstream effector of Shh and Nodal. Misexpression of Pitx2 is sufficient to produce reversed organs of body rotation. Defect of Pitx2 in human may cause Rieger syndrome . Pitx2 seems to be a key conserved signalling molecules that mediates left right asymmetry in vertebrate.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1999年第1期3-5,共3页
Progress In Biochemistry and Biophysics
