蛋白质的结构转换

Structural Transformation of Proteins.

许多不相关的蛋白质含有相同的短肽序列却形成不同的空间构象．结构转换广泛存在于蛋白质折叠和功能过程中，具有重要的生物学意义．综述了Ｓｅｒｐｉｎ和ＥＦＴｕ的失活、血细胞凝集素的激活、蛋白酶成熟、亚基装配和蛋白质淀粉样化等过程中肽链同源肽段的结构转换模式，并讨论了它在理解蛋白质折叠机理和“构象病”病因中的应用．

Many unrelated proteins share identical short peptide sequence but adopt different conformations . Structural transformation that occurs in the process of protein folding and functioning is of great significance in biological organisms . The structural transformation of peptide segment in the process of serpin and EF Tu inactivation, hemagglutinin activation, protease maturation, subunit assembly and protein amyloidosis is reviewed and its implication for the understanding of protein folding and “conformational diseases” is also discussed .