胰岛素受体介导的信号传递

Insulin Receptor Signaling Pathways.

就胰岛素与其受体结合后，信号传递的过程及参与信号传递的细胞内信号分子进行了综述．胰岛素作为一种重要激素，参与机体的新陈代谢，调节细胞的生长分化．其发挥生理功能的第一步是与靶细胞膜上的受体相结合，激活胰岛素受体的酪氨酸激酶活性，随之磷酸化细胞内的信号分子，从而使胰岛素的刺激信号转化为细胞反应．

Insulin is one principal hormone in mammals . It modulates the process of metabolism and promotes cellular growth and differentiation. Its action is mediated through insulin receptor. Insulin binding activates the tyrosine kinase activity of the receptor. The activated receptor frequently undergoes autophosphorylation and then phosphorylates cellular signal molecules, thus making it possible for insulin to elicit the corresponding response. A brief description is given on the process of signal transduction in the cell after insulin stimulation and the cellular signal molecules involved in the process.