建德市肾综合征出血热Ⅰ型灭活疫苗随机对照现场中对照组人群隐性感染定群研究

Cohort Study on Inapparent Infection of HFRS in Control Group -A Randomized Controlled Field of Type Ⅰ Inactivated Vaccine against Hemorrhagic Fever with Renal Syndrome in Jiande County

目的：用定群血清流行病学方法研究ＨＦＲＳ疫苗效果考核现场对照组人群隐性感染情况及感染后抗体水平的变化。方法：采用ＩＦＡＴ检测血清中ＨＦＲＳＩｇＧ抗体，分析不同性别和年龄的隐性感染及感染后抗体水平变化情况。结果：对照组３６０人随访４０个月（１９９４年７月至１９９７年１１月），ＨＦＲＳ年感染率２９３％，不同性别和年龄组未见显著差异；３２名隐性感染者ＨＦＲＳ抗体转阴率４６８８％，也可见ＨＦＲＳ抗体上升率达２５００％，在不同ＨＦＲＳ抗体滴度、性别和年龄组中未见显著差异。

Objective: Cohort study of seroepidemiology on inapparent infection of HFRS and antibody variation after inapparent infection of HFRS in control group was carried out in a randomized controlled field of type Ⅰ inactivated vaccine against HFRS. Methods : Indirect immunofluorescent antibody method was used in testing IgG antibody in sera, seroconversion to HFRS antibody and antibody variation after inapparent infection of HFRS in control group were stratified analysis by sex and age groups. Results: After 40 months followed-up in 360 persons (1994.7～1997.11), year rate of seroconversion to HFRS antibody was 2.93%. There were no statistically significant difference in positive seroconversion rates of sex and age groups; In 32 persons of inapparent infection of HFRS, negative seroconversion rate of antibody to HFRS was 46.88% and rate of antibody increase to HFRS was 25.00%, also there were no statistically significant difference in negative seroconversion rate of antibody and rate of antibody increase of sex、age groups and different HFRS antibody titer. Conclusion: The results showed background data to evaluate the field protection efficacy of an inactivated HFRS vaccine.