摘要
近年来对脂多糖（ＬＰＳ）介导细胞激活的信号转导过程已取得实质性进展。ＬＰＳ与血浆ＬＰＳ结合蛋白（ＬＢＰ）结合被运输到单核巨噬细胞表面，与ｍＣＤ１４受体结合引起细胞激活。ＭＡＰＫ参与了ＬＰＳ激活细胞产生肿瘤坏死因子（ＴＮＦ）等活性物质的细胞内信号转导过程。ｐ３８ＭＡＰＫ对ＴＮＦα等细胞因子具有重要的调节作用。对ＬＰＳ激活细胞的信号转导研究可能为治疗内毒素休克提供新的理论和思路。
Recently there have been some substantial progresses in signal transduction of cell activation by lipopolysaccharide (LPS). After binding with LBP in the plasma, LPS is transported to the cell membrane surface of monocytes, then binds with membrane CD14 to induce cell activation. Mitogen activated protein kinases (MAPKs) take part in the signal transduction of LPS stimulated cell activation to produce bioactive substances including tumor necrosis factor. p38 MAPK is an important regulator for TNF α expression. It is possible to provide new theory and idea for the treatment of septic shock from the studies of signal transduction of cell activation by LPS.
出处
《生理科学进展》
CAS
CSCD
北大核心
1999年第1期29-34,共6页
Progress in Physiological Sciences
基金
美国国立卫生院基金
关键词
中毒性休克
脂多糖
信号转导
CD14
MAPK
Lipopolysaccharide
Signal transduction
Mitogen activated protein kinase
CD14
