氧氟沙星联合卷曲霉素治疗耐多药肺结核观察

Ofloxacin combined capreomycin treatment observation of multi-drug resistant tuberculosis

目的:探讨氧氟沙星联合卷曲霉素治疗方案治疗耐多药肺结核的效果。方法:回顾性分析162例耐多药肺结核病例资料,与同期氧氟沙星和其他抗结核药联用病例对照分析。结果:两组病例疗程结束时,观察组痰菌阴转率明显高于对照组,两组比较差异有统计学意义(P<0.01);观察组空洞转阴率高于对照组,两组比较差异有统计学意义(P<0.01);观察组病灶明显吸收率高于对照组,两组比较差异有统计学意义(P<0.05);观察组复发率与对照组比较差异有统计学意义(P<0.05);观察组的药物不良反应率与对照组比较差异无统计学意义(P>0.05)。结论:氧氟沙星与卷曲霉素的配合治疗能明显提高耐多药肺结核的治疗效果,复发率低,值得临床推广。

Objective Of loxacin in the treatment of combined capreomycin in the treatment of the effect of multi-drug resistant tuberculosis.Methods Retrospective analysis of our hospital during the 162 patients admitted to clinical data of multi-drug resistant tuberculosis.With the same period of ofloxacin and other anti-TB drugs in conjunction with the case-control analysis.Results The two groups were the end of treatment,sputum conversion rate of the observation group was significantly higher,the difference was statistically significant（P〈0.01）;obser vation group empty negative rate was higher,the two groups There was significant difference（P〈0.01）;observation group lesions significantly higher absorption rate,the difference was statistically significant（P〈0.05）;observation group and control group recurrence rate was significantly（P〈0.05）;observation group the rate of adverse drug reactions compared with the control group showed no significant difference（P〉0.05）.Conclusion Capreomycin with Ofloxacin and the treatment could significantly increase the multi-drug resistant tuberculosis treatment,relapse rate is low,worthy to be popularized.