杯状病毒受体研究进展

Progress on Viral Receptors of Caliciviruses

杯状病毒科(Caliciviridae)的病毒是一类多样性的病毒,具有广泛的宿主和组织趋向性。对于其受体的研究,近年来取得了一定的进展。鉴定的受体分子主要集中于两类,一类是碳水化合物,包括组织血型抗原(HBGAs)、唾液酸和硫酸乙酰肝素;另一类是细胞蛋白,如连接黏附分子-A(JAM-A),一种分子质量为105 ku的膜蛋白等。此外,病毒与宿主受体相互识别的分子机制也取得了进展,这些研究对于深入了解病毒与宿主间的相互关系及有针对性地进行抗病毒药物、疫苗的研制具有重大意义。

Caliciviruses are a diverse virus family with a wide range of host and tissue tropisms.Over recent years much progress has been made in identifying receptors of caliciviruses.The receptors of caliciviruses could be divided into two groups.One is carbohydrate,including histo-blood group antigens（HBGAs）,sialic acid,heparan sulfate;another is cellular protein,such as junctional adhension molecular A（JAM-A）,an unkown 105 ku membrane protein.Furthermore,many researches have also revealed the molecular basis of receptor recognition by caliciviruses.These will help to understand the virus-host interactions and will further be helpful for designing and developing anti-viral drugs and vaccines to control and prevent calicivirus infection and illness.